Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9062033 | 0.88 | RAB9A (0.57) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL10332011 | 0.86 | SMN1; SMN2 (0.54) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL9062359 | 0.86 | RAB9A (0.65) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL21816576 | 0.85 | RAB9A (0.44) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL21816553 | 0.85 | RAB9A (0.43) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL21816554 | 0.85 | MAPT (0.43) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL21816578 | 0.85 | RAB9A (0.43) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL9060886 | 0.85 | RAB9A (0.71) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL9061603 | 0.84 | RAB9A (0.70) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL9060960 | 0.84 | RAB9A (0.70) | RAB9ASMN1; SMN2NPC1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240389588-A1 | COMPOUNDS AND METHODS FOR TREATING NEMATODE INFECTIONS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2024-11-28 | — | — | US | disclosed |
| US-12022832-B2 | Compounds and methods for treating nematode infections | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2024-07-02 | — | — | US | disclosed |
| US-12022832-B2 | Compounds and methods for treating nematode infections | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2024-07-02 | — | — | US | disclosed |
| US-12022832-B2 | Compounds and methods for treating nematode infections | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2024-07-02 | — | — | US | disclosed |
| US-20220354117-A1 | COMPOUNDS AND METHODS FOR TREATING NEMATODE INFECTIONS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2022-11-10 | — | — | US | disclosed |
| WO-2020051689-A1 | COMPOUNDS AND METHODS FOR TREATING NEMATODE INFECTIONS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2020-03-19 | — | — | WO | disclosed |
| WO-2020051689-A1 | COMPOUNDS AND METHODS FOR TREATING NEMATODE INFECTIONS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2020-03-19 | — | — | WO | disclosed |
| US-5536442-A | ELECTROOPTICS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-16 | — | — | US | disclosed |
| US-5389292-A | Liquid crystalline media having positive dielctric anisotropy, chemical, heat and radiation resistance, used as electro-optical displaying | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-14 | — | — | US | disclosed |
| EP-0381728-B1 | DIFLUOROMETHYL COMPOUNDS | MERCK PATENT GMBH (DE) | 1993-12-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12022832-B2 | Compounds and methods for treating nematode infections | HNMT, NISCH, HRH2 | RAB9A 2708/4885SMN1; SMN2 1819/4885NPC1 385/4885 |
| US-20220354117-A1 | COMPOUNDS AND METHODS FOR TREATING NEMATODE INFECTIONS | HNMT, NISCH, HRH2 | RAB9A 2708/4885SMN1; SMN2 1819/4885NPC1 385/4885 |
| US-20240389588-A1 | COMPOUNDS AND METHODS FOR TREATING NEMATODE INFECTIONS | HNMT, NISCH, HRH2 | RAB9A 2708/4885SMN1; SMN2 1819/4885NPC1 385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.