Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | CETP | P11597 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.42 |
| ▸ | PPARA | Q07869 | 4/20 | 0.42 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19612759 | 0.94 | UGT2B7 (0.44) | HDAC1HDAC8CETPEPHX1NPC1 | |
| SCHEMBL11319751 | 0.87 | AKR1C3 (0.50) | HDAC1HDAC8CETPEPHX1NPC1 | |
| SCHEMBL2545036 | 0.87 | AKR1C3 (0.50) | HDAC1HDAC8CETPEPHX1NPC1 | |
| SCHEMBL2536993 | 0.87 | AKR1C3 (0.50) | HDAC1HDAC8CETPEPHX1NPC1 | |
| SCHEMBL11316020 | 0.87 | AKR1C3 (0.50) | HDAC1HDAC8CETPEPHX1NPC1 | |
| SCHEMBL11321098 | 0.86 | AKR1C3 (0.51) | HDAC1HDAC8CETPEPHX1NPC1 | |
| SCHEMBL7432230 | 0.82 | ASAH1 (0.48) | NPC1RAB9ASMN1; SMN2MMP1CNR2 | |
| SCHEMBL19612571 | 0.82 | ASAH1 (0.48) | NPC1RAB9ASMN1; SMN2MMP1CNR2 | |
| SCHEMBL7799567 | 0.81 | AKR1C3 (0.52) | HDAC1HDAC8NPC1LMNARAB9A | |
| SCHEMBL19612637 | 0.81 | ASAH1 (0.46) | NPC1LMNARAB9ASMN1; SMN2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5550161-A | COMPOUNDS WHICH CHELATE IRON AND ALUMINUM IONS; TREATMENT OF VARIOUS ANEMIAS, HEMOSIDEROSIS, ALZHEIMER*S DISEASE | ORAL-D (US) | 1996-08-27 | — | — | US | disclosed |
| WO-1992020227-A1 | SUBSTITUTED ORALLY EFFECTIVE ION CHELATORS RELATED TO DEFEROXAMINE | ORAL-D (US) | 1992-11-26 | — | — | WO | disclosed |
| US-5047421-A | Treating trivalent metal overload conditions in humans | ORAL-D (US) | 1991-09-10 | — | — | US | disclosed |
| US-5015664-A | Orally effective ion chelators related to deferoxamine | ORAL D (US) | 1991-05-14 | — | — | US | disclosed |
| US-4684482-A | DEFEROXAMINE DERIVATIVES | ORAL-D (L.P.) (US) | 1987-08-04 | — | — | US | disclosed |
| US-4671901-A | DIFEROXAMINE DERIVATIVES FOR REDUCTION OF METAL ION TUSSUE OV ERLOAD | ORAL-D (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0171414-A1 | ORALLY EFFECTIVE ION CHELATORS RELATED TO DEFEROXAMINE. | ORAL D (US) | 1986-02-19 | — | — | EP | disclosed |
| WO-1985003290-A1 | ORALLY EFFECTIVE ION CHELATORS RELATED TO DEFEROXAMINE | ORAL-D (US) | 1985-08-01 | — | — | WO | disclosed |