Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 14/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 13/20 | 0.65 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.65 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.54 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.54 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.54 |
| ▸ | ALB | P02768 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | RARB | P10826 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345176 | 1.00 | PTGS1 (0.65) | PTGS1PTGS2MT-CO1MT-CO2OPRK1 | |
| SCHEMBL24307189 | 0.98 | PTGS1 (0.67) | PTGS1PTGS2MT-CO1MT-CO2OPRK1 | |
| SCHEMBL9063786 | 0.98 | PTGS1 (0.67) | PTGS1PTGS2MT-CO1MT-CO2OPRK1 | |
| SCHEMBL11195904 | 0.84 | PTGS1 (0.64) | PTGS1PTGS2MT-CO1MT-CO2OPRK1 | |
| SCHEMBL1345174 | 0.82 | LTB4R (0.46) | PTGS1PTGS2MT-CO1MT-CO2OPRK1 | |
| SCHEMBL11185009 | 0.82 | KEAP1 (0.50) | PTGS1PTGS2MT-CO1MT-CO2OPRK1 | |
| SCHEMBL10883113 | 0.82 | PTGS1 (0.94) | PTGS1PTGS2MT-CO1MT-CO2OPRK1 | |
| SCHEMBL9063276 | 0.82 | PTGS1 (0.94) | PTGS1PTGS2MT-CO1MT-CO2OPRK1 | |
| SCHEMBL23190505 | 0.82 | KEAP1 (0.48) | PTGS1PTGS2MT-CO1MT-CO2OPRK1 | |
| SCHEMBL9139198 | 0.82 | PTGS1 (0.94) | PTGS1PTGS2MT-CO1MT-CO2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063242-B2 | for treatment of neutrofil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bollous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis; prevention and treatment of damages caused by ischemia and reperfusion | DOMPE PHA.R.MA S.P.A. (IT) | 2011-11-22 | — | — | US | disclosed |
| US-8063242-B2 | for treatment of neutrofil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bollous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis; prevention and treatment of damages caused by ischemia and reperfusion | DOMPE PHA.R.MA S.P.A. (IT) | 2011-11-22 | — | — | US | disclosed |
| CN-1046935-C | Phenylalkan derivative, preparation of same and seperation of optical isomer of same | HISAMITSU PHARMACEUTICAL CO (JP) | 1999-12-01 | — | — | CN | disclosed |
| EP-0641760-B1 | PHENYLALKANOIC ACID DERIVATIVE, PRODUCTION THEREOF, AND SEPARATION OF OPTICAL ISOMERS THEREOF | HISAMITSU PHARMACEUTICAL CO (JP) | 1996-11-06 | — | — | EP | disclosed |
| CN-1033086-C | Process for producing phenylalkanoic acid derivative | HISAMITSU PHARMACEUTICAL CO (JP) | 1996-10-23 | — | — | CN | disclosed |
| US-5434292-A | Phenylalkanoic acid derivatives, process for producing the same and process for separating optical isomers thereof | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 1995-07-18 | — | — | US | disclosed |
| EP-0641760-A1 | PHENYLALKANOIC ACID DERIVATIVE, PRODUCTION THEREOF, AND SEPARATION OF OPTICAL ISOMERS THEREOF | Hisamitsu Pharmaceutical Co., Inc. (JP) | 1995-03-08 | — | — | EP | disclosed |
| CN-1089935-A | Octadecyloxy phenyl acid derivative, its preparation method and optical isomer separation method thereof | HISAMITSU PHARMACEUTICAL CO (JP) | 1994-07-27 | — | — | CN | disclosed |
| CN-1069484-A | Octadecyloxy phenyl acid derivative, its preparation method and optical isomer separation method thereof | HISAMITSU PHARMACEUTICAL CO (JP) | 1993-03-03 | — | — | CN | disclosed |
| US-4407823-A | ANTIINFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-10-04 | — | — | US | disclosed |
| EP-0007319-A1 | Indan-1-carboxylic acid derivatives,process for their preparation and pharmaceutical preparations containing these compounds | SCHERING AKTIENGESELLSCHAFT (DE) | 1980-02-06 | — | — | EP | disclosed |