Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7717666 | 0.71 | RAB9A (0.37) | RAB9ANPC1AKR1C3AKR1C1L3MBTL1 | |
| SCHEMBL24896549 | 0.71 | PMP22 (0.44) | KMT2AMEN1LMNACHRM2CHRM4 | |
| SCHEMBL5281905 | 0.71 | APOBEC3A (0.37) | KMT2AMEN1POLBRGS12CYP3A4 | |
| Toluene SCHEMBL28973336 | 0.70 | RAB9A (0.53) | RAB9ANPC1AKR1C3AKR1C1L3MBTL1 | |
| Toluene SCHEMBL28973335 | 0.70 | RAB9A (0.53) | RAB9ANPC1AKR1C3AKR1C1L3MBTL1 | |
| Biphenyl SCHEMBL7611759 | 0.69 | RAB9A (0.74) | RAB9ANPC1AKR1C3AKR1C1L3MBTL1 | |
| Iodide SCHEMBL29262460 | 0.69 | PMP22 (0.42) | KMT2AMEN1LMNACHRM2CHRM4 | |
| SCHEMBL30919456 | 0.69 | PMP22 (0.42) | KMT2AMEN1LMNACHRM2CHRM4 | |
| Biphenyl SCHEMBL11881576 | 0.69 | RAB9A (0.74) | RAB9ANPC1AKR1C3AKR1C1L3MBTL1 | |
| SCHEMBL5944513 | 0.69 | APOBEC3A (0.40) | KMT2AMEN1POLBRGS12CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506778-B1 | SUBSTITUTED 4-PHENYL-4-PIPERIDINECARBOXAMIDES WITH BOTH LOCAL ANAESTHETIC AND ANALGESIC EFFECT AS WELL AS PROCESSES FOR THEIR PREPARATION | ASTRA AB (SE) | 1996-05-29 | — | — | EP | disclosed |
| WO-1991009845-A1 | SUBSTITUTED 4-PHENYL-4-PIPERIDINECARBOXAMIDES WITH BOTH LOCAL ANAESTHETIC AND ANALGESIC EFFECT AS WELL AS PROCESSES FOR THEIR PREPARATION | AKTIEBOLAGET ASTRA (SE) | 1991-07-11 | — | — | WO | disclosed |