Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 11/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.80 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.80 |
| ▸ | HPGD | P15428 | 3/20 | 0.80 |
| ▸ | TSHR | P16473 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 2/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.80 |
| ▸ | SCN1A | P35498 | 4/20 | 0.65 |
| ▸ | SCN2A | Q99250 | 4/20 | 0.65 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8378300 | 1.00 | CYP2D6 (0.80) | CYP2D6KDM4EALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL14479807 | 1.00 | CYP2D6 (0.80) | CYP2D6KDM4EALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL9766377 | 0.93 | CYP2D6 (0.80) | CYP2D6KDM4EALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL8467825 | 0.93 | CYP2D6 (0.80) | CYP2D6KDM4EALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL1322372 | 0.93 | CYP2D6 (0.80) | CYP2D6KDM4EALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL17543030 | 0.93 | CYP2D6 (0.80) | CYP2D6KDM4EALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL10066282 | 0.93 | CYP2D6 (0.80) | CYP2D6KDM4EALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL10066281 | 0.93 | CYP2D6 (0.80) | CYP2D6KDM4EALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL522675 | 0.93 | CYP2D6 (0.80) | CYP2D6KDM4EALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL17543192 | 0.93 | CYP2D6 (0.80) | CYP2D6KDM4EALDH1A1HSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383650-B2 | Organic compounds | NOVARTIS AG (CH) | 2013-02-26 | — | — | US | disclosed |
| US-8129411-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20090192148-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-07-30 | — | — | US | disclosed |
| US-20080319018-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192148-A1 | Organic Compounds | REN, ACE, AGTR1 | CYP2D6 479/4885KDM4E 1650/4885ALDH1A1 38/4885 |
| US-20080319018-A1 | ORGANIC COMPOUNDS | REN, ACE, AGTR1 | CYP2D6 148/4885KDM4E 3075/4885ALDH1A1 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.