Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13502435 | 0.84 | AKR1C3 (0.40) | LMNAALDH1A1 | |
| SCHEMBL13502434 | 0.84 | AKR1C3 (0.40) | LMNAALDH1A1 | |
| SCHEMBL13502438 | 0.84 | AKR1C3 (0.40) | LMNAALDH1A1 | |
| SCHEMBL5865837 | 0.80 | AOC3 (0.47) | LMNAMAPK1CES2CES1AOC3 | |
| SCHEMBL31322230 | 0.73 | LMNA (0.44) | LMNAMAPK1CYP2D6SRCCES2 | |
| SCHEMBL5334248 | 0.72 | AOC3 (0.41) | LMNAMAPK1CES2CES1AOC3 | |
| SCHEMBL15114536 | 0.72 | LMNA (0.47) | LMNAMAPK1CYP2D6SRCCES2 | |
| SCHEMBL4394579 | 0.71 | KIF11 (0.46) | CYP2D6ALDH1A1 | |
| SCHEMBL4403169 | 0.71 | KIF11 (0.46) | CYP2D6ALDH1A1 | |
| SCHEMBL44838 | 0.71 | AOC3 (0.47) | LMNAMAPK1CES2CES1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516936-A | TREATMENT OF NEUROLOGICAL DISORDERS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1996-05-14 | — | — | US | disclosed |
| EP-0581907-A4 | — | — | 1994-04-06 | — | — | EP | disclosed |
| US-5254725-A | Inhibitors of kynureninase | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1993-10-19 | — | — | US | disclosed |