Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 4/20 | 0.34 |
| ▸ | CA1 | P00915 | 4/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.34 |
| ▸ | CA9 | Q16790 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8741630 | 0.83 | LMNA (0.36) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL8478713 | 0.77 | LMNA (0.51) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL6537569 | 0.77 | LMNA (0.39) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL27351465 | 0.77 | LMNA (0.36) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL8565364 | 0.76 | LMNA (0.39) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL8557711 | 0.76 | LMNA (0.39) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL6131614 | 0.76 | LMNA (0.52) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL6131605 | 0.74 | CA12 (0.46) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL8473394 | 0.74 | LMNA (0.55) | LMNATHRBCYP2C19KMT2ACA12 | |
| SCHEMBL8741548 | 0.72 | KMT2A (0.47) | LMNATHRBCYP2C19KMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0712315-A1 | RADIOMETAL COMPLEXES THAT LOCALISE IN HYPOXIC TISSUE | AMERSHAM INTERNATIONAL plc (GB) | 1996-05-22 | — | — | EP | disclosed |
| WO-1995004552-A2 | RADIOMETAL COMPLEXES THAT LOCALISE IN HYPOXIC TISSUE | AMERSHAM INTERNATIONAL PLC (GB) | 1995-02-16 | — | — | WO | disclosed |