Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KMO | O15229 | 3/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | FADS1 | O60427 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31520066 | 1.00 | KEAP1 (0.57) | KEAP1KDM4EHIF1ATDP1KMO | |
| SCHEMBL30852503 | 1.00 | KEAP1 (0.57) | KEAP1KDM4EHIF1ATDP1KMO | |
| SCHEMBL8400389 | 1.00 | KEAP1 (0.57) | KEAP1KDM4EHIF1ATDP1KMO | |
| SCHEMBL30852388 | 1.00 | KEAP1 (0.57) | KEAP1KDM4EHIF1ATDP1KMO | |
| SCHEMBL288000 | 0.83 | KDM4E (0.55) | KDM4EHIF1ATDP1KMO | |
| SCHEMBL30853452 | 0.83 | KDM4E (0.55) | KDM4EHIF1ATDP1KMO | |
| SCHEMBL30853450 | 0.83 | KDM4E (0.55) | KDM4EHIF1ATDP1KMO | |
| SCHEMBL17629412 | 0.83 | KDM4E (0.55) | KDM4EHIF1ATDP1KMO | |
| SCHEMBL288161 | 0.83 | KDM4E (0.55) | KDM4EHIF1ATDP1KMO | |
| SCHEMBL30852381 | 0.83 | KDM4E (0.55) | KDM4EHIF1ATDP1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516936-A | TREATMENT OF NEUROLOGICAL DISORDERS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1996-05-14 | — | — | US | disclosed |
| US-5495044-A | Inhibitors of kynureninase | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1996-02-27 | — | — | US | disclosed |
| US-5442104-A | Neurological disorders | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1995-08-15 | — | — | US | disclosed |
| WO-1995011878-A1 | INHIBITORS OF KYNURENINASE | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1995-05-04 | — | — | WO | disclosed |
| EP-0581907-A4 | — | — | 1994-04-06 | — | — | EP | disclosed |
| EP-0581907-A1 | INHIBITORS OF KYNURENINASE | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1994-02-09 | — | — | EP | disclosed |
| US-5254725-A | Inhibitors of kynureninase | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1993-10-19 | — | — | US | disclosed |
| WO-1992018003-A1 | INHIBITORS OF KYNURENINASE | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1992-10-29 | — | — | WO | disclosed |