Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | KMO | O15229 | 3/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.45 |
| ▸ | KYNU | Q16719 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288000 | 1.00 | KDM4E (0.55) | KDM4EHIF1ATDP1KMOSLC7A5 | |
| SCHEMBL30853447 | 1.00 | KDM4E (0.55) | KDM4EHIF1ATDP1KMOSLC7A5 | |
| SCHEMBL30853452 | 1.00 | KDM4E (0.55) | KDM4EHIF1ATDP1KMOSLC7A5 | |
| SCHEMBL30853450 | 1.00 | KDM4E (0.55) | KDM4EHIF1ATDP1KMOSLC7A5 | |
| SCHEMBL30852381 | 1.00 | KDM4E (0.55) | KDM4EHIF1ATDP1KMOSLC7A5 | |
| SCHEMBL17629412 | 1.00 | KDM4E (0.55) | KDM4EHIF1ATDP1KMOSLC7A5 | |
| SCHEMBL4414897 | 0.84 | KMT2A (0.44) | KDM4EHIF1ATDP1SLC7A5KYNU | |
| SCHEMBL8397345 | 0.83 | KMO (0.51) | KDM4EHIF1ATDP1KMOCYP3A4 | |
| SCHEMBL3146454 | 0.83 | KDM4E (0.57) | KDM4EHIF1ATDP1KMOMAPT | |
| SCHEMBL9065248 | 0.83 | KEAP1 (0.57) | KDM4EHIF1ATDP1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250255792-A1 | Methods of Using a Small Molecule Chemical Compound to Reduce the Appearance of Rhytids and Wrinkles | BIRCHBIOMED INC. (CA) | 2025-08-14 | — | — | US | claimed |
| EP-4572737-A1 | METHODS OF USING A SMALL MOLECULE CHEMICAL COMPOUND TO REDUCE THE APPEARANCE OF RHYTIDS AND WRINKLES | Birchbiomed Inc. (CA) | 2025-06-25 | — | — | EP | claimed |
| CN-119894495-A | Method for reducing wrinkle and crease appearance using small molecule compounds | 伯奇生物医药有限公司 | 2025-04-25 | — | — | CN | claimed |
| CN-119104708-A | Application of kynurenine, formyl-5-hydroxykynurenine and 3-methoxy-4-hydroxyphenylethylene glycol as serum biomarker for evaluating curative effect of Crohn disease | 济南微生态生物医学省实验室 | 2024-12-10 | — | — | CN | claimed |
| CN-118910203-A | Application of serum marker in preparation of kit for evaluating curative effect of mesenchymal stem cells on Crohn disease | 济南微生态生物医学省实验室 | 2024-11-08 | — | — | CN | claimed |
| US-20240226085-A1 | KYNRENINE AND DERIVATIVES THEREOF FOR TREATING ATROPHIC SCARRING | BIRCHBIOMED INC. (CA) | 2024-07-11 | — | — | US | claimed |
| WO-2024055116-A1 | METHODS OF USING A SMALL MOLECULE CHEMICAL COMPOUND TO REDUCE THE APPEARANCE OF RHYTIDS AND WRINKLES | BIRCHBIOMED INC. (CA) | 2024-03-21 | — | — | WO | claimed |
| CN-117651553-A | Kynurenine and derivatives thereof for the treatment of atrophic scars | 伯奇生物医药有限公司 | 2024-03-05 | — | — | CN | claimed |
| EP-3197466-B1 | A COMBINATION OF KYNURENINE AND ANTIGEN PRESENTING CELLS (APC) AS THERAPEUTICS AND METHODS FOR THEIR USE IN IMMUNE MODULATION | UNIV BRITISH COLUMBIA (CA) | 2021-02-17 | — | — | EP | claimed |
| US-4882137-A | MELATONIN | GENE LINK AUSTRALIA LIMITED (AU) | 1989-11-21 | — | — | US | claimed |
| US-12551459-B2 | Combination of kynurenine and antigen presenting cells (APC) as therapeutics and methods for their use in immune modulation | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2026-02-17 | — | — | US | disclosed |
| US-20250255792-A1 | Methods of Using a Small Molecule Chemical Compound to Reduce the Appearance of Rhytids and Wrinkles | BIRCHBIOMED INC. (CA) | 2025-08-14 | — | — | US | disclosed |
| EP-4572737-A1 | METHODS OF USING A SMALL MOLECULE CHEMICAL COMPOUND TO REDUCE THE APPEARANCE OF RHYTIDS AND WRINKLES | Birchbiomed Inc. (CA) | 2025-06-25 | — | — | EP | disclosed |
| CN-119894495-A | Method for reducing wrinkle and crease appearance using small molecule compounds | 伯奇生物医药有限公司 | 2025-04-25 | — | — | CN | disclosed |
| CN-119104708-A | Application of kynurenine, formyl-5-hydroxykynurenine and 3-methoxy-4-hydroxyphenylethylene glycol as serum biomarker for evaluating curative effect of Crohn disease | 济南微生态生物医学省实验室 | 2024-12-10 | — | — | CN | disclosed |
| WO-1995011878-A1 | INHIBITORS OF KYNURENINASE | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1995-05-04 | — | — | WO | disclosed |
| EP-0581907-A4 | — | — | 1994-04-06 | — | — | EP | disclosed |
| EP-0581907-A1 | INHIBITORS OF KYNURENINASE | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1994-02-09 | — | — | EP | disclosed |
| US-5254725-A | Inhibitors of kynureninase | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1993-10-19 | — | — | US | disclosed |
| WO-1992018003-A1 | INHIBITORS OF KYNURENINASE | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1992-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12551459-B2 | Combination of kynurenine and antigen presenting cells (APC) as therapeutics and methods for their use in immune modulation | AADAT, IDO1, IAPP | KDM4E 1466/4885HIF1A 1602/4885TDP1 3336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.