Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 4/20 | 0.52 |
| ▸ | EDNRA | P25101 | 4/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7228341 | 1.00 | EDNRB (0.52) | EDNRBEDNRABRD4NPSR1KDM4E | |
| SCHEMBL30637685 | 0.84 | EDNRB (0.59) | EDNRBEDNRANPSR1ALDH1A1TSHR | |
| SCHEMBL7222597 | 0.82 | EDNRB (0.61) | EDNRBEDNRABRD4NPSR1KDM4E | |
| SCHEMBL7228577 | 0.82 | EDNRB (0.61) | EDNRBEDNRANPSR1ALDH1A1 | |
| SCHEMBL9063934 | 0.82 | EDNRB (0.61) | EDNRBEDNRABRD4NPSR1KDM4E | |
| SCHEMBL8473746 | 0.81 | PTGS2 (0.58) | EDNRBEDNRABRD4NPSR1ALDH1A1 | |
| SCHEMBL28724738 | 0.75 | KMT2A (0.64) | EDNRBEDNRABRD4NPSR1KDM4E | |
| SCHEMBL6151621 | 0.74 | EDNRB (0.64) | EDNRBEDNRAALDH1A1TSHRMAPK1 | |
| SCHEMBL6150962 | 0.74 | TSHR (0.58) | EDNRBEDNRAALDH1A1TSHRMAPK1 | |
| SCHEMBL7342871 | 0.74 | EDNRB (0.64) | EDNRBEDNRAALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699191-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994027979-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | IMMUNOPHARMACEUTICS, INC. (US) | 1994-12-08 | — | — | WO | disclosed |