Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.42 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12575473 | 1.00 | ALDH1A1 (0.55) | ALDH1A1MAPTKMT2AEHMT2EHMT1 | |
| SCHEMBL17451463 | 0.99 | ALDH1A1 (0.56) | ALDH1A1MAPTKMT2AEHMT2EHMT1 | |
| SCHEMBL15907910 | 0.93 | ALDH1A1 (0.54) | ALDH1A1MAPTKMT2AEHMT2EHMT1 | |
| SCHEMBL2025649 | 0.89 | ALDH1A1 (0.48) | ALDH1A1MAPTKMT2AEHMT2EHMT1 | |
| SCHEMBL10326593 | 0.87 | EHMT2 (0.55) | ALDH1A1MAPTKMT2AEHMT2EHMT1 | |
| SCHEMBL32664339 | 0.87 | HPGD (0.55) | ALDH1A1MAPTKMT2AHPGDHDAC1 | |
| SCHEMBL17748162 | 0.86 | ALDH1A1 (0.42) | ALDH1A1MAPTKMT2AEHMT2EHMT1 | |
| SCHEMBL17752518 | 0.86 | ALDH1A1 (0.42) | ALDH1A1MAPTKMT2AEHMT2EHMT1 | |
| SCHEMBL98030 | 0.85 | ALDH1A1 (0.73) | ALDH1A1MAPTKMT2AEHMT2EHMT1 | |
| SCHEMBL29811281 | 0.85 | ALDH1A1 (0.73) | ALDH1A1MAPTKMT2AEHMT2EHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160114052-A1 | POTENT CONJUGATES AND HYDROPHILIC LINKERS | IMMUNOGEN, INC. (US) | 2016-04-28 | — | — | US | disclosed |
| US-9150649-B2 | Potent conjugates and hydrophilic linkers | IMMUNOGEN, INC. (US) | 2015-10-06 | — | — | US | disclosed |
| US-20120226026-A1 | POTENT CONJUGATES AND HYDROPHILIC LINKERS | IMMUNOGEN, INC. (US) | 2012-09-06 | — | — | US | disclosed |
| EP-2486023-A1 | POTENT CONJUGATES AND HYDROPHILIC LINKERS | ImmunoGen, Inc. (US) | 2012-08-15 | — | — | EP | disclosed |
| EP-1463558-B1 | CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME | IMMUNOGEN INC (US) | 2012-06-06 | — | — | EP | disclosed |
| EP-2276506-A1 | POTENT CONJUGATES AND HYDROPHILIC LINKERS | Immunogen, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2010126551-A1 | POTENT CONJUGATES AND HYDROPHILIC LINKERS | IMMUNOGEN, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| US-20100129314-A1 | POTENT CONJUGATES AND HYDROPHILIC LINKERS | IMMUNOGEN INC. (US) | 2010-05-27 | — | — | US | disclosed |
| WO-2009134976-A1 | POTENT CONJUGATES AND HYDROPHILIC LINKERS | IMMUNOGEN, INC (US) | 2009-11-05 | — | — | WO | disclosed |
| WO-2009134952-A2 | POTENT CONJUGATES AND HYDROPHILIC LINKERS | IMMUNOGEN, INC (US) | 2009-11-05 | — | — | WO | disclosed |
| EP-1463558-A4 | CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME | IMMUNOGEN INC (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1463558-A2 | CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME | Immunogen, Inc. (US) | 2004-10-06 | — | — | EP | disclosed |
| US-6716821-B2 | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same | IMMUNOGEN INC. | 2004-04-06 | — | — | US | disclosed |
| US-20040001838-A1 | CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME | IMMUNOGEN, INC. | 2004-01-01 | — | — | US | disclosed |
| WO-2003068144-A2 | CYTOTOXIC AGENTS | IMMUNOGEN, INC. (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100129314-A1 | POTENT CONJUGATES AND HYDROPHILIC LINKERS | CD44, EPCAM, ABCG2 | ALDH1A1 1029/4885MAPT 3857/4885KMT2A 3226/4885 |
| US-20120226026-A1 | POTENT CONJUGATES AND HYDROPHILIC LINKERS | CD44, EPCAM, ABCG2 | ALDH1A1 1029/4885MAPT 3857/4885KMT2A 3226/4885 |
| US-20040001838-A1 | CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME | MCL1, CD47, BAX | ALDH1A1 2607/4885MAPT 3489/4885KMT2A 4468/4885 |
| US-20160114052-A1 | POTENT CONJUGATES AND HYDROPHILIC LINKERS | CD44, EPCAM, ABCG2 | ALDH1A1 1029/4885MAPT 3857/4885KMT2A 3226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.