Sugi Predict

Sugi Predict / Compounds / SCHEMBL10326593

SCHEMBL10326593

SCHEMBL10326593

c1ccc(SSCCOCCOCCSSc2ccccn2)nc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EHMT2 Q96KQ7 1/20 0.55
▸ EHMT1 Q9H9B1 1/20 0.55
▸ APOBEC3G Q9HC16 1/20 0.55
▸ ALDH1A1 P00352 3/20 0.40
▸ TDP1 Q9NUW8 2/20 0.38
▸ LMNA P02545 2/20 0.38
▸ HTT P42858 1/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.38
▸ KMT2A Q03164 3/20 0.37
▸ MAPT P10636 1/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ HDAC1 Q13547 3/20 0.37
▸ HDAC2 Q92769 3/20 0.37
▸ NPC1 O15118 3/20 0.37
▸ RAB9A P51151 3/20 0.37
▸ L3MBTL1 Q9Y468 3/20 0.37
▸ MEN1 O00255 2/20 0.36
▸ HPGD P15428 2/20 0.36
▸ TSHR P16473 1/20 0.36
▸ PKM P14618 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11821480 0.98 EHMT2 (0.57) EHMT2EHMT1APOBEC3GALDH1A1TDP1
SCHEMBL15140934 0.92 EHMT2 (0.47) EHMT2EHMT1APOBEC3GALDH1A1TDP1
SCHEMBL30195622 0.92 EHMT2 (0.47) EHMT2EHMT1APOBEC3GALDH1A1TDP1
SCHEMBL14125327 0.92 EHMT2 (0.47) EHMT2EHMT1APOBEC3GALDH1A1TDP1
SCHEMBL31290207 0.92 EHMT2 (0.47) EHMT2EHMT1APOBEC3GALDH1A1TDP1
SCHEMBL18369713 0.92 EHMT2 (0.47) EHMT2EHMT1APOBEC3GALDH1A1TDP1
SCHEMBL29796129 0.92 EHMT2 (0.47) EHMT2EHMT1APOBEC3GALDH1A1TDP1
SCHEMBL28577904 0.92 EHMT2 (0.47) EHMT2EHMT1APOBEC3GALDH1A1TDP1
SCHEMBL31456218 0.92 EHMT2 (0.47) EHMT2EHMT1APOBEC3GALDH1A1TDP1
SCHEMBL14984823 0.90 EHMT2 (0.48) EHMT2EHMT1APOBEC3GALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3114138-B1 IMPROVED MUTEINS OF CLOTTING FACTOR VIII PFIZER (US) 2021-11-17 — — EP disclosed
US-20200392205-A1 MUTEINS OF CLOTTING FACTOR Vlll PFIZER (US) 2020-12-17 — — US disclosed
US-10570189-B2 Muteins of clotting factor VIII PFIZER INC. (US) 2020-02-25 — — US disclosed
EP-3114138-A1 IMPROVED MUTEINS OF CLOTTING FACTOR VIII Pfizer Inc. (US) 2017-01-11 — — EP disclosed
US-9526794-B2 Injectable dendrimer hydrogel nanoparticles WAYNE STATE UNIVERSITY (US) 2016-12-27 — — US disclosed
US-20160311934-A1 HYDROXYALKYL STARCH DERIVATIVES AS REACTANTS FOR COUPLING TO THIOL GROUPS FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2016-10-27 — — US disclosed
US-20160311934-A1 HYDROXYALKYL STARCH DERIVATIVES AS REACTANTS FOR COUPLING TO THIOL GROUPS FRESENIUS KABI DEUTSCHLAND GMBH (DE) 2016-10-27 — — US disclosed
US-9308274-B2 Stabilized polymeric thiol reagents NEKTAR THERAPEUTICS (US) 2016-04-12 — — US disclosed
US-20150306234-A1 MUTEINS OF CLOTTING FACTOR Vlll PFIZER INC. 2015-10-29 — — US disclosed
WO-2015132724-A1 IMPROVED MUTEINS OF CLOTTING FACTOR VIII PFIZER INC. (US) 2015-09-11 — — WO disclosed
US-20140256951-A1 STABILIZED POLYMERIC THIOL REAGENTS NEKTAR THERAPEUTICS (US) 2014-09-11 — — US disclosed
US-8765883-B2 Stabilized polymeric thiol reagents NEKTAR THERAPEUTICS (US) 2014-07-01 — — US disclosed
US-20130280206-A1 STABILIZED POLYMERIC THIOL REAGENTS NEKTAR THERAPEUTICS 2013-10-24 — — US disclosed
US-8492488-B2 Stabilized polymeric thiol reagents NEKTAR THERAPEUTICS (US) 2013-07-23 — — US disclosed
US-20130136697-A1 INJECTABLE DENDRIMER HYDROGEL NANOPARTICLES NATIONAL INSTITUTES OF HEALTH (US) 2013-05-30 — — US disclosed
US-20120258985-A1 STABILIZED POLYMERIC THIOL REAGENTS NEKTAR THERAPEUTICS (US) 2012-10-11 — — US disclosed
US-8217123-B2 Stabilized polymeric thiol reagents NEKTAR THERAPEUTICS (US) 2012-07-10 — — US disclosed
US-20110112277-A1 Stabilized Polymeric Thiol Reagents NEKTAR THERAPEUTICS (US) 2011-05-12 — — US disclosed
US-7851565-B2 For pegylation of biodrugs and drugs; for example, polyethylene glycol with pyridyldithioalkoxy end groups; allows target amino acid for attachment, to be cysteine instead of lysine which can inactive some peptide drugs NEKTAR THERAPEUTICS (US) 2010-12-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160311934-A1 HYDROXYALKYL STARCH DERIVATIVES AS REACTANTS FOR COUPLING TO THIOL GROUPS MSR1, C3AR1, C1R EHMT2 2564/4885EHMT1 2832/4885APOBEC3G 4205/4885
US-20200392205-A1 MUTEINS OF CLOTTING FACTOR Vlll F8, F13B, F5 EHMT2 4150/4885EHMT1 4400/4885APOBEC3G 330/4885
US-20130280206-A1 STABILIZED POLYMERIC THIOL REAGENTS TST, STS, SCLY EHMT2 3587/4885EHMT1 3434/4885APOBEC3G 3427/4885
US-20110112277-A1 Stabilized Polymeric Thiol Reagents TST, CD44, MPST EHMT2 3580/4885EHMT1 3452/4885APOBEC3G 3646/4885
US-20130136697-A1 INJECTABLE DENDRIMER HYDROGEL NANOPARTICLES UACA, PAM, JAK3 EHMT2 2854/4885EHMT1 3579/4885APOBEC3G 275/4885
US-20140256951-A1 STABILIZED POLYMERIC THIOL REAGENTS TST, TTPA, MPST EHMT2 2099/4885EHMT1 2089/4885APOBEC3G 3272/4885
US-20120258985-A1 STABILIZED POLYMERIC THIOL REAGENTS TST, STS, CD44 EHMT2 3711/4885EHMT1 3475/4885APOBEC3G 3398/4885
US-10570189-B2 Muteins of clotting factor VIII F8, F13B, F7 EHMT2 4190/4885EHMT1 4476/4885APOBEC3G 160/4885
US-20150306234-A1 MUTEINS OF CLOTTING FACTOR Vlll F8, F13B, F5 EHMT2 4150/4885EHMT1 4400/4885APOBEC3G 330/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.