Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.85 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.85 |
| ▸ | LMNA | P02545 | 1/20 | 0.85 |
| ▸ | RECQL | P46063 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533646 | 0.94 | POLB (0.97) | POLBSMN1; SMN2LMNARECQLTSHR | |
| SCHEMBL11037821 | 0.89 | POLB (0.87) | POLBSMN1; SMN2LMNARECQLTSHR | |
| SCHEMBL30943574 | 0.88 | POLB (0.85) | POLBSMN1; SMN2LMNARECQLTSHR | |
| SCHEMBL18672819 | 0.87 | POLB (0.84) | POLBSMN1; SMN2LMNARECQLTSHR | |
| SCHEMBL9405372 | 0.85 | POLB (0.73) | POLBSMN1; SMN2LMNARECQLTSHR | |
| SCHEMBL465225 | 0.83 | SMN1; SMN2 (0.77) | POLBSMN1; SMN2LMNARECQLTSHR | |
| SCHEMBL2380518 | 0.80 | POLB (0.72) | POLBSMN1; SMN2LMNARECQLTSHR | |
| SCHEMBL12544736 | 0.79 | SMN1; SMN2 (0.71) | POLBSMN1; SMN2LMNARECQLTSHR | |
| SCHEMBL5594520 | 0.78 | POLB (0.65) | POLBSMN1; SMN2LMNARECQLTSHR | |
| SCHEMBL5594524 | 0.78 | POLB (0.65) | POLBSMN1; SMN2LMNARECQLTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690713-A1 | SUBSTITUTED ALICYCLIC AMINE-CONTAINING MACROCYCLIC IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021254-A1 | SUBSTITUTED ALICYCLIC AMINE-CONTAINING MACROCYCLIC IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 1994-09-29 | — | — | WO | disclosed |