Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9067490 | 1.00 | MAPT (0.49) | MAPTHPGDMEN1KMT2ACRHBP | |
| SCHEMBL3839304 | 0.84 | MAPT (0.54) | MAPTHPGDMEN1KMT2ACRHBP | |
| SCHEMBL3839303 | 0.84 | MAPT (0.54) | MAPTHPGDMEN1KMT2ACRHBP | |
| SCHEMBL518603 | 0.84 | MAPT (0.50) | MAPTHPGDMEN1KMT2ACRHBP | |
| SCHEMBL14691525 | 0.84 | CRHR1 (0.40) | MAPTHPGDMEN1KMT2ACRHBP | |
| SCHEMBL14691523 | 0.84 | CRHR1 (0.40) | MAPTHPGDMEN1KMT2ACRHBP | |
| SCHEMBL9068060 | 0.83 | ALDH1A1 (0.51) | MAPTHPGDHTTSMN1; SMN2CRHR1 | |
| SCHEMBL9068062 | 0.83 | ALDH1A1 (0.51) | MAPTHPGDHTTSMN1; SMN2CRHR1 | |
| SCHEMBL20364255 | 0.80 | CA1 (0.50) | MAPTHPGDMEN1KMT2AHTT | |
| SCHEMBL9068343 | 0.80 | CA1 (0.50) | MAPTHPGDMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506228-A | 2,6-diaryl pyridazinones with immunosuppressant activity | MERCK & CO., INC. (US) | 1996-04-09 | — | — | US | disclosed |