Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 4/20 | 0.40 |
| ▸ | ACE | P12821 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14417102 | 0.84 | GPR139 (0.52) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL1055212 | 0.84 | GPR139 (0.52) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL9067252 | 0.82 | GPR139 (0.59) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL9067712 | 0.82 | GPR139 (0.48) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL8595095 | 0.81 | GPR139 (0.55) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL8123489 | 0.80 | GPR139 (0.71) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL8123498 | 0.80 | GPR139 (0.71) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL9067654 | 0.80 | GPR139 (0.47) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL28286556 | 0.80 | MME (0.39) | MMEACEL3MBTL1OPRD1OPRM1 | |
| SCHEMBL8132701 | 0.78 | MME (0.44) | GPR139KMT2AALDH1A1MAPTMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534497-A | RADIOPHARMACEUTICALS; MEDICAL DIAGNOSIS | MALLINCKRODT MEDICAL, INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5187264-A | Technetium chelates to be used for determining the renal function | MALLINCKRODT MEDICAL, INC. (US) | 1993-02-16 | — | — | US | disclosed |
| EP-0250013-B1 | TECHNETIUM CHELATES TO BE USED FOR DETERMINING THE RENAL FUNCTION | MALLINCKRODT, INC.(a Missouri corporation) (US) | 1990-05-09 | — | — | EP | disclosed |
| US-4849511-A | Technetium chelates to be used for determining the renal function | MALLINCKRODT, INC. (US) | 1989-07-18 | — | — | US | disclosed |
| EP-0250013-A1 | Technetium chelates to be used for determining the renal function | MALLINCKRODT, INC.(a Missouri corporation) (US) | 1987-12-23 | — | — | EP | disclosed |