Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PPID | Q08752 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9067652 | 0.82 | GPR139 (0.57) | GPR139ALDH1A1KMT2AMAPTHTT | |
| SCHEMBL9067252 | 0.81 | GPR139 (0.59) | GPR139ALDH1A1KMT2AMAPTHTT | |
| SCHEMBL9068127 | 0.81 | NOD2 (0.43) | GPR139ALDH1A1NOD2PPIDKDM4E | |
| SCHEMBL16135529 | 0.76 | ALDH1A1 (0.53) | GPR139ALDH1A1POLBRXFP1KDM4E | |
| SCHEMBL10949832 | 0.74 | CYP1A2 (0.55) | PPIDKMT2AMEN1 | |
| SCHEMBL10949836 | 0.74 | CYP1A2 (0.55) | PPIDKMT2AMEN1 | |
| SCHEMBL19034783 | 0.74 | GPR139 (0.54) | GPR139ALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL18113085 | 0.73 | KMT2A (0.55) | GPR139ALDH1A1POLBRXFP1KMT2A | |
| SCHEMBL11098136 | 0.73 | GPR139 (0.54) | GPR139ALDH1A1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL8123498 | 0.72 | GPR139 (0.71) | GPR139ALDH1A1KDM4ESMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534497-A | RADIOPHARMACEUTICALS; MEDICAL DIAGNOSIS | MALLINCKRODT MEDICAL, INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5187264-A | Technetium chelates to be used for determining the renal function | MALLINCKRODT MEDICAL, INC. (US) | 1993-02-16 | — | — | US | disclosed |
| EP-0250013-B1 | TECHNETIUM CHELATES TO BE USED FOR DETERMINING THE RENAL FUNCTION | MALLINCKRODT, INC.(a Missouri corporation) (US) | 1990-05-09 | — | — | EP | disclosed |
| US-4849511-A | Technetium chelates to be used for determining the renal function | MALLINCKRODT, INC. (US) | 1989-07-18 | — | — | US | disclosed |
| EP-0250013-A1 | Technetium chelates to be used for determining the renal function | MALLINCKRODT, INC.(a Missouri corporation) (US) | 1987-12-23 | — | — | EP | disclosed |