Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319768 | 0.84 | DHFR (0.64) | DHFRSLC2A1 | |
| Bromide SCHEMBL9542002 | 0.83 | DHFR (0.63) | DHFRSLC2A1 | |
| SCHEMBL8454805 | 0.81 | DHFR (0.51) | DHFRSLC2A1 | |
| SCHEMBL10465515 | 0.79 | DHFR (0.74) | DHFRSLC2A1 | |
| SCHEMBL5462527 | 0.79 | DHFR (0.58) | DHFRSLC2A1 | |
| SCHEMBL8468661 | 0.79 | DHFR (0.43) | DHFRSLC2A1 | |
| SCHEMBL30092875 | 0.78 | DHFR (0.52) | DHFRSLC2A1 | |
| SCHEMBL27188510 | 0.78 | DHFR (0.52) | DHFRSLC2A1 | |
| SCHEMBL10052933 | 0.75 | DHFR (0.82) | DHFR | |
| SCHEMBL10644399 | 0.72 | DHFR (0.78) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4725687-A | ANTITUMOR AGENTS; SIDE EFFECT REDUCTION; POTENCY | SOUTHERN RESEARCH INSTITUTE (US) | 1988-02-16 | — | — | US | claimed |
| US-5536724-A | Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10-dideazaaminopterins | SRI INTERNATIONAL (US) | 1996-07-16 | — | — | US | disclosed |
| EP-0638079-A1 | DEAZAAMINOPTERINS FOR TREATMENT OF INFLAMMATION | SRI INTERNATIONAL (US) | 1995-02-15 | — | — | EP | disclosed |
| WO-1993022312-A1 | DEAZAAMINOPTERINS FOR TREATMENT OF INFLAMMATION | SRI INTERNATIONAL (US) | 1993-11-11 | — | — | WO | disclosed |
| US-4725687-A | ANTITUMOR AGENTS; SIDE EFFECT REDUCTION; POTENCY | SOUTHERN RESEARCH INSTITUTE (US) | 1988-02-16 | — | — | US | disclosed |