Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.81 |
| ▸ | MMP2 | P08253 | 1/20 | 0.71 |
| ▸ | MMP7 | P09237 | 1/20 | 0.71 |
| ▸ | MMP9 | P14780 | 1/20 | 0.71 |
| ▸ | MMP12 | P39900 | 1/20 | 0.71 |
| ▸ | MMP13 | P45452 | 1/20 | 0.71 |
| ▸ | ECE1 | P42892 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9751225 | 1.00 | MME (0.81) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL4371284 | 0.90 | MME (0.72) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL8895948 | 0.90 | MMP1 (0.72) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL8895943 | 0.90 | MMP1 (0.72) | MMEMMP2MMP7MMP9MMP12 | |
| SCHEMBL8249769 | 0.89 | MME (1.00) | MME | |
| SCHEMBL2679032 | 0.89 | MME (1.00) | MME | |
| SCHEMBL5869271 | 0.89 | MME (1.00) | MME | |
| SCHEMBL5869412 | 0.89 | MME (1.00) | MME | |
| SCHEMBL2679035 | 0.89 | MME (1.00) | MME | |
| SCHEMBL11438800 | 0.89 | MME (0.79) | MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496805-A | DIURETIC, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1996-03-05 | — | — | US | disclosed |
| EP-0358660-A4 | SYNTHETIC INHIBITORS OF MAMMALIAN COLLAGENASE | — | 1991-01-09 | — | — | EP | disclosed |
| EP-0358660-A1 | SYNTHETIC INHIBITORS OF MAMMALIAN COLLAGENASE. | RES CORP TECHNOLOGIES INC (US) | 1990-03-21 | — | — | EP | disclosed |
| WO-1988006890-A1 | SYNTHETIC INHIBITORS OF MAMMALIAN COLLAGENASE | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1988-09-22 | — | — | WO | disclosed |