Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12286757 | 0.87 | LMNA (0.58) | LMNATDP1L3MBTL1KDM4ETSHR | |
| SCHEMBL15840781 | 0.81 | TDP1 (0.71) | LMNATDP1L3MBTL1KDM4ETSHR | |
| SCHEMBL28074963 | 0.81 | TDP1 (0.71) | LMNATDP1L3MBTL1KDM4ETSHR | |
| SCHEMBL7123818 | 0.81 | TDP1 (0.71) | LMNATDP1L3MBTL1KDM4ETSHR | |
| SCHEMBL17467946 | 0.81 | LMNA (0.50) | LMNATDP1L3MBTL1KDM4ETSHR | |
| SCHEMBL18076293 | 0.81 | TDP1 (0.71) | LMNATDP1L3MBTL1KDM4ETSHR | |
| SCHEMBL28002563 | 0.79 | LMNA (0.61) | LMNATDP1L3MBTL1KDM4ETSHR | |
| SCHEMBL7153546 | 0.79 | LMNA (0.54) | LMNATDP1L3MBTL1KDM4ETSHR | |
| SCHEMBL14147720 | 0.78 | LMNA (0.69) | LMNATDP1L3MBTL1KDM4ETSHR | |
| SCHEMBL12153722 | 0.78 | LMNA (0.69) | LMNATDP1L3MBTL1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188215-B2 | Metal-binding compounds and uses therefor | AMPIO PHARMACEUTICALS, INC. | 2012-05-29 | — | — | US | disclosed |
| US-8017728-B2 | Metal-binding compounds and uses therefor | AMPIO PHARMACEUTICALS, INC. | 2011-09-13 | — | — | US | disclosed |
| US-20100144644-A1 | METAL-BINDING COMPOUNDS AND USES THEREFOR | DMI LIFE SCIENCES INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-7632803-B2 | Metal-binding compounds and uses therefor | DMI LIFE SCIENCES, INC. (US) | 2009-12-15 | — | — | US | disclosed |