Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.48 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375696 | 0.90 | ACE (0.53) | HTT | |
| SCHEMBL9068701 | 0.87 | FOLH1 (0.52) | GRIA1FOLH1 | |
| SCHEMBL9069506 | 0.83 | HTT (0.48) | HTTPTGER4MEN1ALDH1A1HPGD | |
| SCHEMBL11296564 | 0.81 | ATM (0.52) | FOLH1 | |
| SCHEMBL10420650 | 0.81 | TACR1 (0.57) | ALDH1A1KMT2A | |
| SCHEMBL2875581 | 0.77 | HTT (0.88) | HTTPTGER4MEN1KMT2AFOLH1 | |
| SCHEMBL125577 | 0.77 | HTT (0.88) | HTTPTGER4MEN1KMT2AFOLH1 | |
| SCHEMBL4858734 | 0.77 | HTT (0.88) | HTTPTGER4MEN1KMT2AFOLH1 | |
| SCHEMBL3693087 | 0.77 | HTT (0.88) | HTTPTGER4MEN1KMT2AFOLH1 | |
| SCHEMBL3694316 | 0.77 | HTT (0.88) | HTTPTGER4MEN1KMT2AFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496805-A | DIURETIC, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1996-03-05 | — | — | US | disclosed |