Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.49 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11296564 | 0.95 | ATM (0.52) | FOLH1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL650610 | 0.89 | ACE (0.59) | NAALAD2 | |
| SCHEMBL391211 | 0.89 | ACE (0.59) | NAALAD2 | |
| SCHEMBL5603448 | 0.89 | ACE (0.59) | NAALAD2 | |
| SCHEMBL9069505 | 0.87 | HTT (0.54) | FOLH1GRIA1 | |
| SCHEMBL7380315 | 0.84 | MMEL1 (0.64) | — | |
| SCHEMBL7385743 | 0.84 | MMEL1 (0.64) | — | |
| SCHEMBL9068706 | 0.81 | FOLH1 (0.45) | FOLH1 | |
| SCHEMBL7385019 | 0.81 | MME (0.64) | NAALAD2 | |
| SCHEMBL9365219 | 0.80 | MME (0.57) | NAALAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496805-A | DIURETIC, HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1996-03-05 | — | — | US | disclosed |