Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.50 |
| ▸ | PTGFR | P43088 | 1/20 | 0.48 |
| ▸ | GCK | P35557 | 13/20 | 0.47 |
| ▸ | RARA | P10276 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
| ▸ | RARG | P13631 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654259 | 0.86 | GCK (0.51) | HCAR3PTGFRGCKRARARARB | |
| SCHEMBL5233630 | 0.74 | HCAR3 (0.56) | HCAR3GCKRARARARBRARG | |
| SCHEMBL4737042 | 0.74 | GRM5 (0.44) | NPC1RAB9ASMN1; SMN2HCRTR1TP53 | |
| SCHEMBL2666296 | 0.74 | GCK (0.77) | HCAR3GCKRARARARBRARG | |
| SCHEMBL5235844 | 0.72 | HCAR3 (0.68) | HCAR3PTGFRGCKNPC1RAB9A | |
| SCHEMBL11564378 | 0.72 | HCAR3 (0.61) | HCAR3 | |
| SCHEMBL5236663 | 0.71 | HCAR3 (0.66) | HCAR3PTGFRGCKNPC1RAB9A | |
| SCHEMBL20913335 | 0.71 | HCAR3 (0.56) | HCAR3PTGFRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4675406 | 0.71 | GCK (0.60) | HCAR3PTGFRGCKRARARARB | |
| SCHEMBL2653449 | 0.71 | GCK (0.63) | HCAR3GCKRARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004045614-A1 | QUINOLINE DERIVATIVES AS GLUCOKINASE LIGANDS | ASTRAZENECA AB (SE) | 2004-06-03 | — | — | WO | disclosed |