Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 12/20 | 0.51 |
| ▸ | RARA | P10276 | 1/20 | 0.50 |
| ▸ | RARB | P10826 | 1/20 | 0.50 |
| ▸ | RARG | P13631 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.46 |
| ▸ | PTGFR | P43088 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737042 | 0.88 | GRM5 (0.44) | MAPTNPC1HCRTR1TP53NFKB1 | |
| SCHEMBL9070804 | 0.86 | HCAR3 (0.50) | GCKRARARARBRARGHCAR3 | |
| SCHEMBL4740261 | 0.81 | ALOX15 (0.60) | MAPTTDP1P2RY12ALOX15SGMS2 | |
| SCHEMBL2666296 | 0.79 | GCK (0.77) | GCKRARARARBRARGHCAR3 | |
| SCHEMBL14505783 | 0.74 | GCK (0.71) | GCKRARARARBRARG | |
| SCHEMBL2653449 | 0.74 | GCK (0.63) | GCKRARARARBRARGHCAR3 | |
| SCHEMBL5451958 | 0.73 | GCK (0.65) | GCKRARARARBRARG | |
| SCHEMBL4675406 | 0.73 | GCK (0.60) | GCKRARARARBRARGHCAR3 | |
| SCHEMBL31389312 | 0.73 | NR1H4 (0.49) | P2RY12 | |
| SCHEMBL2656240 | 0.72 | GCK (0.65) | GCKRARARARBRARGHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583532-B1 | QUINOLINE DERIVATIVES AS GLUCOKINASE LIGANDS | ASTRAZENECA AB (SE) | 2008-07-16 | — | — | EP | claimed |
| US-20060079553-A1 | Quinoline derivatives as glucokinase ligands | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | US | claimed |
| EP-1583532-A1 | QUINOLINE DERIVATIVES AS GLUCOKINASE LIGANDS | Astrazeneca AB (SE) | 2005-10-12 | — | — | EP | claimed |
| WO-2004045614-A1 | QUINOLINE DERIVATIVES AS GLUCOKINASE LIGANDS | ASTRAZENECA AB (SE) | 2004-06-03 | — | — | WO | claimed |
| EP-1583532-B1 | QUINOLINE DERIVATIVES AS GLUCOKINASE LIGANDS | ASTRAZENECA AB (SE) | 2008-07-16 | — | — | EP | disclosed |
| US-7230108-B2 | Quinoline derivatives as glucokinase ligands | ASTRAZENECA AB (SE) | 2007-06-12 | — | — | US | disclosed |
| US-7230108-B2 | Quinoline derivatives as glucokinase ligands | ASTRAZENECA AB (SE) | 2007-06-12 | — | — | US | disclosed |
| US-7230108-B2 | Quinoline derivatives as glucokinase ligands | ASTRAZENECA AB (SE) | 2007-06-12 | — | — | US | disclosed |
| US-20060079553-A1 | Quinoline derivatives as glucokinase ligands | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | US | disclosed |
| EP-1583532-A1 | QUINOLINE DERIVATIVES AS GLUCOKINASE LIGANDS | Astrazeneca AB (SE) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004045614-A1 | QUINOLINE DERIVATIVES AS GLUCOKINASE LIGANDS | ASTRAZENECA AB (SE) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079553-A1 | Quinoline derivatives as glucokinase ligands | GCK, GCKR, GALK1 | GCK 1/4885RARA 3044/4885RARB 3025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.