Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667346 | 0.93 | GCK (0.56) | GCKKCNH2 | |
| SCHEMBL9071016 | 0.91 | GCK (0.51) | GCKKCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL2667769 | 0.91 | GCK (0.58) | GCKKCNH2SCD | |
| SCHEMBL2667778 | 0.91 | GCK (0.49) | GCKKCNH2CYP2D6ADORA2ANPC1 | |
| SCHEMBL9070812 | 0.89 | GCK (0.54) | GCKKCNH2NPC1RAB9AALDH1A1 | |
| SCHEMBL2667351 | 0.87 | GCK (0.48) | GCKKCNH2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2667345 | 0.86 | GCK (0.58) | GCKKCNH2 | |
| SCHEMBL9070817 | 0.84 | ALDH1A1 (0.51) | GCKALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2667573 | 0.84 | GCK (0.67) | GCKKCNH2 | |
| SCHEMBL2667975 | 0.84 | GCK (0.65) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |