Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 12/20 | 0.54 |
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667348 | 0.93 | GCK (0.59) | GCKGRM5KCNH2MAPK1ALDH1A1 | |
| SCHEMBL9070839 | 0.91 | POLB (0.47) | GCKGRM5POLBMAPK1SMN1; SMN2 | |
| SCHEMBL2667781 | 0.90 | GCK (0.50) | GCKGRM5KCNH2POLBSCD | |
| SCHEMBL2667351 | 0.90 | GCK (0.48) | GCKKCNH2MAPK1SMN1; SMN2LMNA | |
| SCHEMBL9070817 | 0.89 | ALDH1A1 (0.51) | GCKPOLBMAPK1SMN1; SMN2LMNA | |
| SCHEMBL9070815 | 0.89 | GCK (0.51) | GCKKCNH2SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2667345 | 0.85 | GCK (0.58) | GCKKCNH2 | |
| SCHEMBL9070966 | 0.84 | GRM5 (0.50) | GCKGRM5SMN1; SMN2MAPTHPGD | |
| SCHEMBL9070969 | 0.84 | GCK (0.54) | GCKKCNH2 | |
| SCHEMBL9070816 | 0.83 | GCK (0.58) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |