Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 1/20 | 0.59 |
| ▸ | GCK | P35557 | 13/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | MAPK4 | P31152 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667761 | 0.92 | GCK (0.56) | AGERGCKADORA2ARAB9AHSD17B10 | |
| SCHEMBL9071031 | 0.89 | GCK (0.60) | AGERGCKADORA2ARAB9ANPC1 | |
| SCHEMBL9070999 | 0.89 | RAB9A (0.63) | GCKRAB9ANPC1KCNH2MAPK1 | |
| SCHEMBL2667731 | 0.88 | GCK (0.58) | GCKRAB9AHSD17B10NPC1KCNH2 | |
| SCHEMBL9070934 | 0.86 | GCK (0.63) | GCKKCNH2 | |
| SCHEMBL2658908 | 0.86 | GCK (0.76) | GCKKCNH2 | |
| SCHEMBL2667777 | 0.86 | GCK (0.55) | GCKRAB9AHSD17B10NPC1KCNH2 | |
| SCHEMBL9070836 | 0.86 | GCK (0.55) | GCKADORA2ARAB9AHSD17B10NPC1 | |
| SCHEMBL9070935 | 0.85 | GCK (0.58) | GCKRAB9ANPC1 | |
| SCHEMBL9071042 | 0.83 | GCK (0.62) | GCKHSD17B10KCNH2MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |