Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667818 | 0.89 | GCK (0.59) | GCKRAB9ANPC1KCNH2 | |
| SCHEMBL2667980 | 0.89 | GCK (0.47) | GCKRAB9ANPC1HSD17B10MEN1 | |
| SCHEMBL9070999 | 0.88 | RAB9A (0.63) | GCKRAB9ANPC1KCNH2MEN1 | |
| SCHEMBL2667731 | 0.87 | GCK (0.58) | GCKRAB9ANPC1HSD17B10KCNH2 | |
| SCHEMBL2653763 | 0.87 | GCK (0.73) | GCKKCNH2 | |
| SCHEMBL9071042 | 0.86 | GCK (0.62) | GCKHSD17B10KCNH2MEN1KMT2A | |
| SCHEMBL9070925 | 0.86 | AGER (0.59) | GCKRAB9ANPC1HSD17B10KCNH2 | |
| SCHEMBL2667761 | 0.86 | GCK (0.56) | GCKRAB9ANPC1HSD17B10MEN1 | |
| SCHEMBL2667777 | 0.85 | GCK (0.55) | GCKRAB9ANPC1HSD17B10KCNH2 | |
| SCHEMBL2658908 | 0.85 | GCK (0.76) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |