Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.43 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11555321 | 0.84 | APEX1 (0.47) | APEX1EPHX2PTGS2MAP1LC3BMAP1LC3A | |
| SCHEMBL2202083 | 0.84 | APEX1 (0.50) | APEX1EPHX2PTGS2MAP1LC3BMAP1LC3A | |
| SCHEMBL1991282 | 0.84 | APEX1 (0.69) | APEX1EPHX2PTGS2MAP1LC3BMAP1LC3A | |
| SCHEMBL19014549 | 0.84 | MEN1 (0.58) | APEX1HPGDCYP1A2CYP2C9HSD17B10 | |
| SCHEMBL8175041 | 0.82 | APEX1 (0.49) | APEX1EPHX2PTGS2MAP1LC3BMAP1LC3A | |
| SCHEMBL7696215 | 0.82 | EPHX2 (0.55) | APEX1EPHX2PTGS2MAP1LC3BMAP1LC3A | |
| SCHEMBL11436094 | 0.81 | THRB (0.49) | APEX1PTGS2MAP1LC3BMAP1LC3A | |
| SCHEMBL16956435 | 0.81 | APEX1 (0.46) | APEX1EPHX2PTGS2MAP1LC3BMAP1LC3A | |
| SCHEMBL28425375 | 0.81 | L3MBTL1 (0.57) | APEX1PTGS2HPGDCYP1A2CYP2C9 | |
| SCHEMBL10389972 | 0.80 | SMN1; SMN2 (0.54) | HPGDHSD17B10SMN1; SMN2MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2133099-B1 | Conjugated biological molecules and their preparation | POLYTHERICS LTD (GB) | 2017-04-19 | — | — | EP | disclosed |
| US-9439974-B2 | Conjugated biological molecules and their preparation | POLYTHERICS LIMITED (GB) | 2016-09-13 | — | — | US | disclosed |
| EP-2253330-B1 | Conjugated biological molecules and their preparation | POLYTHERICS LTD (GB) | 2015-08-19 | — | — | EP | disclosed |
| EP-2277550-B1 | Process for the preparation of conjugated biological molecules. | POLYTHERICS LTD (GB) | 2015-04-29 | — | — | EP | disclosed |
| US-20140369960-A1 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION | ABZENA (CAMBRIDGE) LIMITED (GB) | 2014-12-18 | — | — | US | disclosed |
| US-8816051-B2 | Conjugated biological molecules and their preparation | POLYTHERICS LIMITED (GB) | 2014-08-26 | — | — | US | disclosed |
| US-20110182855-A1 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION | POLYTHERICS LIMITED (GB) | 2011-07-28 | — | — | US | disclosed |
| US-7939630-B2 | Conjugated biological molecules and their preparation | POLYTHERICS LIMITED (GB) | 2011-05-10 | — | — | US | disclosed |
| EP-2277550-A1 | Conjugated biological molecules and their preparation | Polytherics Limited (GB) | 2011-01-26 | — | — | EP | disclosed |
| EP-2253330-A2 | Conjugated biological molecules and their preparation | Polytherics Limited (GB) | 2010-11-24 | — | — | EP | disclosed |
| EP-2133099-A2 | Conjugated biological molecules and their preparation | Polytherics Limited (GB) | 2009-12-16 | — | — | EP | disclosed |
| US-20090298154-A1 | Conjugated biological molecules and their preparation | POLYTHERICS LIMITED (GB) | 2009-12-03 | — | — | US | disclosed |
| US-7595292-B2 | Conjugated biological molecules and their preparation | POLYTHERICS LIMITED (GB) | 2009-09-29 | — | — | US | disclosed |
| EP-1648518-B1 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION | POLYTHERICS LTD (GB) | 2009-08-26 | — | — | EP | disclosed |
| US-20060210526-A1 | polyoxyethylene glycol-protein conjugate linked via linking group | ABZENA (CAMBRIDGE) LIMITED (GB) | 2006-09-21 | — | — | US | disclosed |
| EP-1648518-A2 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION | Polytherics Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005007197-A2 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION | POLYTHERICS LIMITED (GB) | 2005-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140369960-A1 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION | F13B, F13A1, ZYX | APEX1 278/4885EPHX2 878/4885PTGS2 1912/4885 |
| US-20110182855-A1 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION | F13B, ZYX, F13A1 | APEX1 117/4885EPHX2 929/4885PTGS2 1832/4885 |
| US-20090298154-A1 | Conjugated biological molecules and their preparation | F13B, ZYX, F13A1 | APEX1 117/4885EPHX2 929/4885PTGS2 1832/4885 |
| US-20060210526-A1 | polyoxyethylene glycol-protein conjugate linked via linking group | F13A1, F13B, SSB | APEX1 316/4885EPHX2 873/4885PTGS2 3034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.