Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.39 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL907315 | 0.85 | STAT3 (0.53) | STAT3LMNAMAPTMEN1KMT2A | |
| SCHEMBL907200 | 0.83 | SIRT1 (0.42) | LMNAMAPTSIRT1POLBSIRT2 | |
| Hydrochloric Acid SCHEMBL907378 | 0.83 | SIRT1 (0.52) | SIRT1SIRT2 | |
| SCHEMBL3405827 | 0.83 | MAPT (0.38) | LMNAMAPTMEN1KMT2ACA1 | |
| SCHEMBL907439 | 0.73 | SIRT1 (0.55) | SIRT1SIRT2 | |
| SCHEMBL907583 | 0.72 | NR1H4 (0.54) | MAPTMEN1KMT2ACA1CA2 | |
| SCHEMBL907521 | 0.70 | NAMPT (0.46) | LMNAMAPTSIRT1 | |
| SCHEMBL907350 | 0.70 | SIRT1 (0.70) | SIRT1SIRT2 | |
| SCHEMBL3850008 | 0.69 | EPHX2 (0.57) | LMNAMAPTMEN1KMT2ASIRT1 | |
| SCHEMBL29665279 | 0.68 | STAT3 (0.44) | STAT3CTDSP1SIRT5ENPP1ENPP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501991-B2 | P53 activating compounds | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2013-08-06 | — | — | US | disclosed |
| US-20110021529-A1 | P53 ACTIVATING COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2011-01-27 | — | — | US | disclosed |
| EP-2099445-A2 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | University Court of The University of Dundee (GB) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008029096-A2 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021529-A1 | P53 ACTIVATING COMPOUNDS | TP53, TP53BP1, SIRT1 | STAT3 82/4885CTDSP1 1228/4885SIRT5 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.