Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.54 |
| ▸ | ESRRG | P62508 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850008 | 0.86 | EPHX2 (0.57) | NR1H4EPHX2HDAC3HDAC11HDAC8 | |
| SCHEMBL907521 | 0.85 | NAMPT (0.46) | NR1H4EPHX2HDAC3HDAC11HDAC8 | |
| SCHEMBL907337 | 0.83 | EPHX2 (0.51) | NR1H4EPHX2ESRRGHDAC3HDAC11 | |
| SCHEMBL3400607 | 0.83 | EPHX2 (0.51) | NR1H4EPHX2ESRRGHDAC3HDAC11 | |
| SCHEMBL907439 | 0.82 | SIRT1 (0.55) | NR1H4HDAC3HDAC11HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL3400227 | 0.82 | EPHX2 (0.50) | NR1H4EPHX2ESRRGHDAC3HDAC11 | |
| SCHEMBL907350 | 0.81 | SIRT1 (0.70) | SIRT1 | |
| SCHEMBL8218803 | 0.79 | NR1H4 (0.63) | NR1H4EPHX2ESRRGHDAC3HDAC11 | |
| SCHEMBL7947659 | 0.79 | KIF11 (0.49) | NR1H4EPHX2ESRRGHDAC3HDAC11 | |
| SCHEMBL23352874 | 0.79 | HDAC3 (0.75) | NR1H4EPHX2ESRRGHDAC3HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501991-B2 | P53 activating compounds | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2013-08-06 | — | — | US | disclosed |
| US-20110021529-A1 | P53 ACTIVATING COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2011-01-27 | — | — | US | disclosed |
| EP-2099445-B1 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | UNIV DUNDEE (GB) | 2010-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021529-A1 | P53 ACTIVATING COMPOUNDS | TP53, TP53BP1, SIRT1 | NR1H4 2245/4885EPHX2 4403/4885ESRRG 609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.