Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 17/20 | 0.63 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10708164 | 0.91 | CYP19A1 (0.62) | CYP19A1NR3C1CYP17A1 | |
| SCHEMBL8999931 | 0.89 | CYP19A1 (0.67) | CYP19A1NR3C1CYP17A1 | |
| SCHEMBL2118371 | 0.88 | NR3C1 (0.64) | CYP19A1NR3C1CYP17A1 | |
| SCHEMBL8999936 | 0.88 | NR3C1 (0.64) | CYP19A1NR3C1CYP17A1 | |
| SCHEMBL9356635 | 0.86 | CYP19A1 (0.56) | CYP19A1NR3C1CYP17A1 | |
| SCHEMBL9356884 | 0.86 | CYP19A1 (0.56) | CYP19A1NR3C1CYP17A1 | |
| SCHEMBL9356926 | 0.84 | CYP19A1 (0.54) | CYP19A1NR3C1CYP17A1 | |
| SCHEMBL8668371 | 0.84 | CYP19A1 (0.54) | CYP19A1NR3C1CYP17A1 | |
| SCHEMBL9360771 | 0.84 | CYP19A1 (0.53) | CYP19A1NR3C1CYP17A1 | |
| SCHEMBL11332229 | 0.83 | CYP19A1 (0.57) | CYP19A1NR3C1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0350488-B1 | 1,2-DEHYDROGENATION OF STEROIDAL 21-ESTERS WITH A. SIMPLEX | THE UPJOHN COMPANY (US) | 1993-09-08 | — | — | EP | claimed |
| EP-0350488-A1 | 1,2-DEHYDROGENATION OF STEROIDAL 21-ESTERS WITH A. SIMPLEX. | UPJOHN CO (US) | 1990-01-17 | — | — | EP | claimed |
| WO-1988007092-A1 | 1,2-DEHYDROGENATION OF STEROIDAL 21-ESTERS WITH A. SIMPLEX | THE UPJOHN COMPANY (US) | 1988-09-22 | — | — | WO | claimed |
| CN-116410939-A | 3-sterone-delta 1 Dehydrogenase mutant and application thereof in synthesis of steroid C1,2 dehydrogenation drug intermediates | 中国科学院天津工业生物技术研究所 | 2023-07-11 | — | — | CN | disclosed |
| US-5506354-A | ANTIULCER, ANTITURMOR, ANTIARTHRITIC, ANTIATHEROSCLEROSIS, ANTIALLERGIC, ANTIASTHMA AGENTS | THE UPJOHN COMPANY (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0238545-B1 | C20 THROUGH C26 AMINO STEROIDS | UPJOHN CO (US) | 1995-11-15 | — | — | EP | disclosed |
| US-RE35053-E | Intermediates for amino substituted steroids | THE UPJOHN COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| EP-0263213-B1 | C20 Through C26 amino steroids | UPJOHN CO (US) | 1995-09-06 | — | — | EP | disclosed |
| US-5382661-A | Useful in treating spinal trauma, head injury, subarachnoid hemorrhage | THE UPJOHN COMPANY (US) | 1995-01-17 | — | — | US | disclosed |
| US-5380841-A | Steroids as antiinflammatory agents | THE UPJOHN COMPANY (US) | 1995-01-10 | — | — | US | disclosed |
| US-5380839-A | Antitumor agents, antisecretory agents, enzyme inhibitors or antiasthmatics | THE UPJOHN COMPANY (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1988007092-A1 | 1,2-DEHYDROGENATION OF STEROIDAL 21-ESTERS WITH A. SIMPLEX | THE UPJOHN COMPANY (US) | 1988-09-22 | — | — | WO | disclosed |
| EP-0263213-A1 | C20 Through C26 amino steroids | THE UPJOHN COMPANY (US) | 1988-04-13 | — | — | EP | disclosed |
| US-4704455-A | 16α-methylatedΔ17(20)-corticoids | THE UPJOHN COMPANY (US) | 1987-11-03 | — | — | US | disclosed |
| EP-0238545-A1 | C 20? THROUGH C 26? AMINO STEROIDS. | UPJOHN CO (US) | 1987-09-30 | — | — | EP | disclosed |
| WO-1987001706-A2 | C20 THROUGH C26 AMINO STEROIDS | THE UPJOHN COMPANY (US) | 1987-03-26 | — | — | WO | disclosed |
| EP-0175540-A2 | 20-Silyl ether steroids, and preparing 17-hydroxy-20-keto steroids | THE UPJOHN COMPANY (US) | 1986-03-26 | — | — | EP | disclosed |
| US-4568492-A | HYDROSILYLATION THEN PERACID OXIDATION | THE UPJOHN COMPANY (US) | 1986-02-04 | — | — | US | disclosed |
| EP-0127216-A1 | Process for the preparation of 21-hydroxy-20-keto-delta16-steroids and intermediate compounds formed in this process | ROUSSEL-UCLAF (FR) | 1984-12-05 | — | — | EP | disclosed |
| EP-0123736-A1 | New process for the preparation of 21-hydroxy-20-keto-delta 16-steroids and new intermediate compounds formed in this process | GIST-BROCADES N.V. (NL) | 1984-11-07 | — | — | EP | disclosed |