Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 10/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.61 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3400231 | 0.99 | SIRT1 (0.62) | SIRT1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL12067341 | 0.93 | SIRT1 (0.71) | SIRT1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL3850011 | 0.92 | SIRT1 (0.57) | SIRT1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL28662121 | 0.90 | SIRT1 (0.68) | SIRT1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3400605 | 0.89 | SIRT1 (0.64) | SIRT1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3400226 | 0.87 | SIRT1 (0.62) | SIRT1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL907582 | 0.87 | SIRT1 (0.65) | SIRT1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL12940302 | 0.87 | SIRT1 (0.65) | SIRT1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL16677197 | 0.87 | MIF (0.66) | SIRT1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL2344788 | 0.87 | KMT2A (0.68) | SIRT1ALDH1A1LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115724780-B | Acylthiourea compound based on hydrophobic tag, preparation method thereof and application of acylthiourea compound in resisting influenza A virus | 武汉大学 | 2024-04-26 | — | — | CN | claimed |
| CN-112807294-B | Application of acyl thiourea compound in preparation of medicines for treating or preventing herpes simplex virus type I infection | 武汉大学 | 2023-09-05 | — | — | CN | claimed |
| CN-110478344-B | Application of acylthiourea compound in preparation of anti-influenza B virus medicine | 武汉大学 | 2022-07-19 | — | — | CN | claimed |
| CN-113582969-A | Application of acylthiourea compound in preparation of anti-enterovirus drugs | 武汉大学 | 2021-11-02 | — | — | CN | claimed |
| CN-112807294-A | Application of acylthiourea compound in preparation of medicine for treating or preventing herpes simplex virus I-type infection | 武汉大学 | 2021-05-18 | — | — | CN | claimed |
| CN-109096836-B | Fluororubber composition | 广州弗西林橡塑有限公司 | 2021-04-06 | — | — | CN | claimed |
| CN-110483425-A | A kind of application of the acyl thiourea compound and preparation method thereof with anti-influenza A virus | UNIV WUHAN | 2019-11-22 | — | — | CN | claimed |
| US-20170128393-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | SIGA TECHNOLOGIES, INC. (US) | 2017-05-11 | — | — | US | claimed |
| EP-2865668-A2 | Inhibitors and methods of inhibiting bacterial and viral pathogens | Siga Technologies, Inc. (US) | 2015-04-29 | — | — | EP | claimed |
| US-20130195796-A1 | Inhibitors and Methods of Inhibiting Bacterial and Viral Pathogens | SIGA TECHNOLOGIES INC. (US) | 2013-08-01 | — | — | US | claimed |
| EP-2536286-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | Siga Technologies, Inc. (US) | 2012-12-26 | — | — | EP | claimed |
| WO-2011103375-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | SIGA TECHNOLOGIES, INC. (US) | 2011-08-25 | — | — | WO | claimed |
| CN-112807294-B | Application of acyl thiourea compound in preparation of medicines for treating or preventing herpes simplex virus type I infection | 武汉大学 | 2023-09-05 | — | — | CN | disclosed |
| CN-110478344-B | Application of acylthiourea compound in preparation of anti-influenza B virus medicine | 武汉大学 | 2022-07-19 | — | — | CN | disclosed |
| CN-113582969-B | Application of acylthiourea compound in preparation of anti-enterovirus drugs | 武汉大学 | 2022-06-14 | — | — | CN | disclosed |
| CN-113582969-A | Application of acylthiourea compound in preparation of anti-enterovirus drugs | 武汉大学 | 2021-11-02 | — | — | CN | disclosed |
| EP-2099445-B1 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | UNIV DUNDEE (GB) | 2010-11-17 | — | — | EP | disclosed |
| EP-2099445-A2 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | University Court of The University of Dundee (GB) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008029096-A2 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2008-03-13 | — | — | WO | disclosed |
| WO-2008029096-A2 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130195796-A1 | Inhibitors and Methods of Inhibiting Bacterial and Viral Pathogens | TST, TPMT, EIF2AK2 | SIRT1 2419/4885ALDH1A1 3069/4885LMNA 4633/4885 |
| US-20170128393-A1 | INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS | TST, TPMT, EIF2AK2 | SIRT1 2419/4885ALDH1A1 3069/4885LMNA 4633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.