Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 12/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 8/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL907381 | 0.85 | SIRT1 (0.67) | SIRT1SIRT2SIRT3HDAC1CA1 | |
| SCHEMBL907521 | 0.84 | NAMPT (0.46) | SIRT1HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL907439 | 0.83 | SIRT1 (0.55) | SIRT1SIRT2SIRT3HDAC1HDAC3 | |
| SCHEMBL907350 | 0.82 | SIRT1 (0.70) | SIRT1SIRT2SIRT3 | |
| SCHEMBL31203496 | 0.78 | CA1 (0.63) | HDAC1CA1CA2HDAC3GBA1 | |
| SCHEMBL30405032 | 0.76 | CA1 (0.55) | HDAC1CA1CA2HDAC3GBA1 | |
| SCHEMBL30091843 | 0.76 | CA1 (0.55) | HDAC1CA1CA2HDAC3GBA1 | |
| SCHEMBL907583 | 0.76 | NR1H4 (0.54) | SIRT1CA1CA2HDAC3HDAC11 | |
| SCHEMBL31203382 | 0.75 | CA1 (0.59) | HDAC1CA1CA2HDAC3GBA1 | |
| SCHEMBL5243757 | 0.75 | CA1 (0.59) | HDAC1CA1CA2HDAC3GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501991-B2 | P53 activating compounds | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2013-08-06 | — | — | US | disclosed |
| US-20110021529-A1 | P53 ACTIVATING COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2011-01-27 | — | — | US | disclosed |
| EP-2099445-B1 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | UNIV DUNDEE (GB) | 2010-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021529-A1 | P53 ACTIVATING COMPOUNDS | TP53, TP53BP1, SIRT1 | SIRT1 3/4885SIRT2 6/4885SIRT3 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.