Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.39 |
| ▸ | RXRB | P28702 | 4/20 | 0.39 |
| ▸ | RXRG | P48443 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.38 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.38 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11949124 | 0.90 | KDM4E (0.40) | RXRARXRBRXRGKDM4EALDH1A1 | |
| SCHEMBL8733215 | 0.89 | ESR1 (0.39) | RXRARXRBRXRGKDM4EALDH1A1 | |
| SCHEMBL2091025 | 0.87 | RXRA (0.41) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL8981801 | 0.81 | RXRA (0.39) | RXRARXRBRXRGMAPTCYP26A1 | |
| SCHEMBL13318246 | 0.80 | KDM1A (0.39) | RXRARXRBRXRGCYP3A4TSHR | |
| SCHEMBL4365965 | 0.80 | CYP26B1 (0.55) | RXRARXRBRXRGKDM4EALDH1A1 | |
| SCHEMBL7207050 | 0.79 | SKP2 (0.42) | RXRAALDH1A1 | |
| SCHEMBL10339561 | 0.78 | ESR1 (0.41) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL6017346 | 0.77 | RXRA (0.39) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL2093706 | 0.77 | PDK2 (0.38) | RXRARXRBRXRGPDK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699178-A1 | TETRAHYDRONAPHTHYL AND CYCLOPROPYL SUBSTITUTED 1,3-BUTADIENES HAVING RETINOID-LIKE ACTIVITY | ALLERGAN, INC. (US) | 1996-03-06 | — | — | EP | disclosed |