Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.39 |
| ▸ | RXRB | P28702 | 3/20 | 0.39 |
| ▸ | RXRG | P48443 | 3/20 | 0.39 |
| ▸ | RARA | P10276 | 2/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18740982 | 0.90 | RARA (0.41) | RXRARXRBRXRGRARARARB | |
| SCHEMBL6017377 | 0.89 | RXRA (0.39) | RXRARXRBRXRGRARARARB | |
| SCHEMBL8981801 | 0.81 | RXRA (0.39) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL2091025 | 0.80 | RXRA (0.41) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL13318246 | 0.80 | KDM1A (0.39) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL4440994 | 0.80 | RARA (0.56) | RXRARXRBRXRGRARARARB | |
| SCHEMBL18741112 | 0.79 | ESR2 (0.41) | RXRARXRBRXRGRARARARB | |
| SCHEMBL2093706 | 0.77 | PDK2 (0.38) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL9075009 | 0.77 | RXRA (0.39) | RXRARXRBRXRGRARARARB | |
| SCHEMBL6507886 | 0.77 | RXRA (0.40) | RXRARXRBRXRGPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1704139-A1 | DISUBSTITUTED CHALCONE OXIMES AS SELECTIVE AGONISTS OF RAR y RETINOID RECEPTORS | Allergan, Inc. (US) | 2006-09-27 | — | — | EP | disclosed |
| WO-2005066116-A1 | DISUBSTITUTED CHALCONE OXIMES AS SELECTIVE AGONISTS OF RARϜ RETINOID RECEPTORS | ALLERGAN, INC. (US) | 2005-07-21 | — | — | WO | disclosed |