Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.73 |
| ▸ | PTAFR | P25105 | 9/20 | 0.70 |
| ▸ | FNTA | P49354 | 4/20 | 0.66 |
| ▸ | FNTB | P49356 | 4/20 | 0.66 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.61 |
| ▸ | HTR2A | P28223 | 2/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.61 |
| ▸ | HTR2B | P41595 | 2/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | SLC6A15 | Q9H2J7 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30056292 | 0.86 | HRH1 (0.80) | HRH1PTAFRFNTAFNTBCHRM2 | |
| SCHEMBL9073792 | 0.86 | HRH1 (0.80) | HRH1PTAFRFNTAFNTBCHRM2 | |
| SCHEMBL30055185 | 0.84 | HRH1 (1.00) | HRH1PTAFRFNTAFNTBCHRM2 | |
| SCHEMBL9075423 | 0.84 | HRH1 (1.00) | HRH1PTAFRFNTAFNTBCHRM2 | |
| SCHEMBL9073587 | 0.83 | HRH1 (0.75) | HRH1PTAFRFNTAFNTBCHRM2 | |
| SCHEMBL9073638 | 0.83 | SLC6A15 (0.78) | HRH1PTAFRFNTAFNTBCHRM2 | |
| SCHEMBL8879303 | 0.83 | PTAFR (0.74) | HRH1PTAFRFNTAFNTBCHRM2 | |
| SCHEMBL8877892 | 0.82 | PTAFR (1.00) | HRH1PTAFRFNTAFNTBCHRM2 | |
| SCHEMBL8889945 | 0.79 | SLC6A15 (0.78) | HRH1PTAFRFNTAFNTBCHRM2 | |
| SCHEMBL9374596 | 0.78 | PTAFR (0.91) | HRH1PTAFRFNTAFNTBCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563134-B1 | AGENTS FOR POTENTIATING THE EFFECTS OF ANTITUMOR AGENTS AND COMBATING MULTIPLE DRUG RESISTANCE | WELLCOME FOUND (GB) | 1996-06-19 | — | — | EP | claimed |
| US-5416091-A | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance | BURROUGHS WELLCOME CO. (US) | 1995-05-16 | — | — | US | claimed |
| EP-0042544-B1 | NOVEL ANTIHISTAMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1984-10-03 | — | — | EP | claimed |
| EP-0042544-A2 | Novel antihistamines, process for their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1981-12-30 | — | — | EP | claimed |
| US-4282233-A | NO SEDATIVE EFFECT | SCHERING CORPORATION (US) | 1981-08-04 | — | — | US | claimed |
| US-5416091-A | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance | BURROUGHS WELLCOME CO. (US) | 1995-05-16 | — | — | US | disclosed |
| US-4831042-A | Tricyclic-substituted piperidine antihistamines | SCHERING CORPORATION (US) | 1989-05-16 | — | — | US | disclosed |
| US-4560688-A | NON-SEDATING; CARBAMOYL OR SULFONAMIDE DERIVATIVES | SCHERING CORPORATION (US) | 1985-12-24 | — | — | US | disclosed |
| EP-0042544-B1 | NOVEL ANTIHISTAMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1984-10-03 | — | — | EP | disclosed |
| US-4454143-A | Tricyclic antihistamines | SCHERING CORPORATION (US) | 1984-06-12 | — | — | US | disclosed |
| US-4355036-A | Tricyclic-substituted piperidine antihistamines | SCHERING CORPORATION (US) | 1982-10-19 | — | — | US | disclosed |
| EP-0042544-A2 | Novel antihistamines, process for their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1981-12-30 | — | — | EP | disclosed |
| US-4282233-A | NO SEDATIVE EFFECT | SCHERING CORPORATION (US) | 1981-08-04 | — | — | US | disclosed |