SCHEMBL9075427

SCHEMBL9075427

COC(=O)Cc1sc(Cl)nc1C=Cc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
KDM4E B2RXH2 3/20 0.41
APOBEC3G Q9HC16 1/20 0.41
SMN1; SMN2 Q16637 4/20 0.41
HPGD P15428 3/20 0.41
GAA P10253 2/20 0.41
GLA P06280 1/20 0.41
NPC1 O15118 4/20 0.40
RAB9A P51151 4/20 0.40
POLB P06746 2/20 0.40
TP53 P04637 1/20 0.40
HSD17B10 Q99714 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C19 P33261 1/20 0.40
PKM P14618 1/20 0.39
NFKB1 P19838 1/20 0.39
NFKB2 Q00653 1/20 0.39
RELA Q04206 1/20 0.39
PTGS2 P35354 1/20 0.39
ACACA Q13085 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9075422 1.00 ALDH1A1 (0.41) ALDH1A1KDM4EAPOBEC3GSMN1; SMN2HPGD
SCHEMBL9074428 0.86 GAA (0.43) ALDH1A1KDM4EAPOBEC3GSMN1; SMN2HPGD
SCHEMBL9074423 0.86 GAA (0.43) ALDH1A1KDM4EAPOBEC3GSMN1; SMN2HPGD
SCHEMBL8965614 0.85 PTGDR2 (0.42) ALDH1A1KDM4EHPGDGAAPOLB
SCHEMBL9076604 0.83 ALDH1A1 (0.40) ALDH1A1KDM4EAPOBEC3GSMN1; SMN2HPGD
SCHEMBL9076607 0.83 ALDH1A1 (0.40) ALDH1A1KDM4EAPOBEC3GSMN1; SMN2HPGD
SCHEMBL9076256 0.78 ALDH1A1 (0.41) ALDH1A1KDM4EAPOBEC3GSMN1; SMN2HPGD
SCHEMBL9076258 0.78 ALDH1A1 (0.41) ALDH1A1KDM4EAPOBEC3GSMN1; SMN2HPGD
SCHEMBL9667281 0.72 GAA (0.45) ALDH1A1KDM4EAPOBEC3GSMN1; SMN2HPGD
SCHEMBL9075300 0.72 ALDH1A1 (0.39) ALDH1A1KDM4ESMN1; SMN2HPGDGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5508414-A FUNGICIDES ROUSSEL UCLAF (FR) 1996-04-16 US disclosed
US-5420340-A Chemical intermediates for fungicides ROUSSEL UCLAF (FR) 1995-05-30 US disclosed
US-5304653-A Fungicides ROUSSEL-UCLAF (FR) 1994-04-19 US disclosed