Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefotaxime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 0.92 |
| ▸ | MAPT | P10636 | 3/20 | 0.92 |
| ▸ | PPARG | P37231 | 2/20 | 0.92 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.92 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.92 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.92 |
| ▸ | ALB | P02768 | 1/20 | 0.92 |
| ▸ | HTR2C | P28335 | 1/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.79 |
| ▸ | APEX1 | P27695 | 3/20 | 0.79 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 2/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | PKM | P14618 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | POLB | P06746 | 1/20 | 0.79 |
| ▸ | RECQL | P46063 | 1/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefotaxime SCHEMBL5441797 | 0.96 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL5441795 | 0.96 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL17422140 | 0.96 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL1583477 | 0.96 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL2220120 | 0.96 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL14594281 | 0.96 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL15410 | 0.96 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL9395572 | 0.96 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL10748430 | 0.96 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL3731937 | 0.96 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583216-A | Methods for the manufacture of cephems | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-10 | — | — | US | disclosed |
| US-4973684-A | Cephem compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-11-27 | — | — | US | disclosed |
| US-4912212-A | Cephem compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-03-27 | — | — | US | disclosed |
| US-4668783-A | Thiazolylacetamido cephalosporin compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-05-26 | — | — | US | disclosed |
| US-4514565-A | Thiazolylacetamido cephalosphorin compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1985-04-30 | — | — | US | disclosed |
| US-4355160-A | Thiazolylacetamido cephalosporin type compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-10-19 | — | — | US | disclosed |
| US-4298606-A | Thiazolylacetamido compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-11-03 | — | — | US | disclosed |
| US-4205180-A | CHEMICAL INTERMEDIATES FOR NOVEL CEPHALOSPORIN COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-05-27 | — | — | US | disclosed |
| US-4203899-A | Thiazolylacetamido compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-05-20 | — | — | US | disclosed |
| US-4098888-A | THIAZOLYLACETAMIDO CEPHALOSPORIN TYPE COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1978-07-04 | — | — | US | disclosed |