Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 15/20 | 0.56 |
| ▸ | HTR6 | P50406 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9076330 | 0.81 | F2 (0.54) | F2 | |
| SCHEMBL9075662 | 0.76 | F2 (0.53) | F2 | |
| SCHEMBL9075654 | 0.76 | F2 (0.53) | F2 | |
| SCHEMBL9073775 | 0.75 | F2 (0.48) | F2 | |
| SCHEMBL25273355 | 0.73 | HTR6 (0.59) | HTR6HTR1AHTR1BHTR7HTR2B | |
| SCHEMBL9076336 | 0.72 | F2 (0.47) | F2 | |
| SCHEMBL8154518 | 0.72 | F2 (1.00) | F2 | |
| SCHEMBL7349871 | 0.72 | F2 (0.58) | F2 | |
| SCHEMBL9073858 | 0.72 | F2 (1.00) | F2 | |
| SCHEMBL9075817 | 0.72 | F2 (1.00) | F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0623596-A1 | N-acylpyrrolidines or N-acylpiperidines having a guanidinyl- or amidinyl-substituted side chain as thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-11-09 | — | — | EP | disclosed |