Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MITF | O75030 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | EIF4A1 | P60842 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9077993 | 0.81 | KDM4E (0.49) | MAPTALDH1A1SMN1; SMN2NPSR1HTT | |
| SCHEMBL9078927 | 0.78 | PARP1 (0.47) | ALDH1A1MEN1KMT2AHTTLMNA | |
| SCHEMBL9219060 | 0.77 | KDM4E (0.45) | MAPTALDH1A1SMN1; SMN2NPSR1HTT | |
| SCHEMBL9078669 | 0.77 | MAPT (0.40) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL9038865 | 0.76 | HASPIN (0.38) | MAPTMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL9077636 | 0.75 | CDK2 (0.47) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL9684699 | 0.74 | ALDH1A1 (0.42) | MAPTMAPK1ALDH1A1AKR1B1MEN1 | |
| SCHEMBL9039039 | 0.71 | KMT2A (0.41) | MAPTMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL9208479 | 0.71 | MAPT (0.37) | MAPTALDH1A1SORT1MEN1KMT2A | |
| SCHEMBL9214349 | 0.71 | MAPT (0.40) | MAPTMAPK1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585382-A | ANTICARCINOGENIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-17 | — | — | US | disclosed |
| US-5416089-A | Antitumor agent | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-05-16 | — | — | US | disclosed |
| WO-1995000490-A1 | BIS-IMIDE POLYCYCLIC AND HETEROCYCLIC CHROMOPHORES USEFUL AS TUMORICIDALS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-01-05 | — | — | WO | disclosed |