Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | BRD4 | O60885 | 1/20 | 0.60 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | TOP2A | P11388 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9080951 | 0.91 | KDM4E (0.74) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL10915570 | 0.85 | ALDH1A1 (0.80) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL11023756 | 0.84 | ALDH1A1 (0.79) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL9078272 | 0.84 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL8775530 | 0.83 | KDM4E (0.74) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL9080323 | 0.82 | KDM4E (0.68) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL9079201 | 0.81 | LMNA (0.61) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL9080289 | 0.81 | KDM4E (0.60) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL9080438 | 0.81 | KDM4E (0.55) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL9080171 | 0.81 | KDM4E (0.58) | ALDH1A1KDM4EHPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508428-A | Spiro compound | DAIICHI PHAMACEUTICAL CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| US-5286723-A | Spiro compound | DAIICHI SEIYAKU CO., LTD. | 1994-02-15 | — | — | US | disclosed |
| EP-0357047-B1 | Spiro compounds | DAIICHI SEIYAKU CO (JP) | 1993-11-03 | — | — | EP | disclosed |
| EP-0529688-A2 | Azaspiro n,m alkanes and diazaspiro n,m -alkanes | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| EP-0357047-A1 | Spiro compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-03-07 | — | — | EP | disclosed |