Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 5/20 | 0.32 |
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL377017 | 0.80 | KMT2A (0.32) | MEN1KMT2ATDP1TP53TSHR | |
| SCHEMBL11892171 | 0.74 | LMNA (0.31) | MITFTSHRLMNAGAA | |
| SCHEMBL1823686 | 0.72 | — | — | |
| SCHEMBL30523484 | 0.72 | MITF (0.30) | MITF | |
| SCHEMBL3823363 | 0.71 | KMT2A (0.40) | MEN1KMT2AL3MBTL1TDP1MAPT | |
| SCHEMBL3225051 | 0.71 | MITF (0.53) | MITFMEN1KMT2ATDP1RAB9A | |
| SCHEMBL6968831 | 0.71 | KMT2A (0.41) | MEN1KMT2AL3MBTL1TDP1MAPT | |
| SCHEMBL47577 | 0.69 | MITF (0.36) | MITFMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL11904538 | 0.69 | TDP1 (0.45) | MEN1KMT2AL3MBTL1TDP1MAPT | |
| Hydrochloric Acid SCHEMBL11703876 | 0.69 | MITF (0.51) | MITFMEN1KMT2ATDP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0296110-B1 | Staurosporine derivatives substituted for the nitrogen atom of the methylamino group | CIBA GEIGY AG (CH) | 1996-02-21 | — | — | EP | disclosed |
| US-5449664-A | Nucleosides | SYNTEX (U.S.A.) INC. (US) | 1995-09-12 | — | — | US | disclosed |
| EP-0300966-B1 | PROCESS FOR THE SELECTIVE N-ACYLATION OF AMINO-HYDRAXAMIC AND DERIVATES AND STARTING COMPOUNDS THEREFOR | CIBA-GEIGY AG (CH) | 1992-10-14 | — | — | EP | disclosed |
| EP-0346281-B1 | CARBAMOYLATED HYDROXAMIC-ACID DERIVATIVES, AND PROCESS FOR THEIR PREPARATION | CIBA-GEIGY AG (CH) | 1992-06-17 | — | — | EP | disclosed |
| EP-0457326-A1 | Antiviral agents | SYNTEX (U.S.A.) INC. (US) | 1991-11-21 | — | — | EP | disclosed |
| EP-0271443-B1 | N,N'-DISUBSTITUTED UREAS AND PROCESS FOR THEIR PRODUCTION | CIBA-GEIGY AG (CH) | 1990-10-17 | — | — | EP | disclosed |
| EP-0346281-A1 | Carbamoylated hydroxamic-acid derivatives, and process for their preparation | CIBA-GEIGY AG (CH) | 1989-12-13 | — | — | EP | disclosed |
| EP-0300966-A2 | Process for the selective N-acylation of amino-hydraxamic and derivates and starting compounds therefor | CIBA-GEIGY AG (CH) | 1989-01-25 | — | — | EP | disclosed |
| EP-0271443-A1 | N,N'-disubstituted ureas and process for their production | CIBA-GEIGY AG (CH) | 1988-06-15 | — | — | EP | disclosed |
| EP-0054514-A1 | Derivatives of aminopapulacandin having antibiotic activity | CIBA-GEIGY AG (CH) | 1982-06-23 | — | — | EP | disclosed |
| EP-0049683-A2 | Imidazo-rifamycines, process for their preparation, pharmaceutical preparations containing them and their use | CIBA-GEIGY AG (CH) | 1982-04-14 | — | — | EP | disclosed |
| EP-0023885-A1 | Method for the introduction of an oxygen-containing functional group into ansamycines, compounds thus obtained, and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1981-02-11 | — | — | EP | disclosed |