Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601376 | 0.81 | AOC3 (0.50) | AOC3SMN1; SMN2POLBTSHRL3MBTL1 | |
| SCHEMBL9078674 | 0.80 | AOC3 (0.48) | AOC3SMN1; SMN2POLBTSHRL3MBTL1 | |
| SCHEMBL5091164 | 0.79 | POLB (0.43) | SMN1; SMN2POLBTSHRL3MBTL1RAB9A | |
| SCHEMBL7258758 | 0.79 | SMN1; SMN2 (0.52) | AOC3SMN1; SMN2POLBTSHRL3MBTL1 | |
| SCHEMBL6601841 | 0.78 | AOC3 (0.47) | AOC3SMN1; SMN2POLBTSHRL3MBTL1 | |
| SCHEMBL22231486 | 0.78 | AOC3 (0.47) | AOC3SMN1; SMN2POLBTSHRL3MBTL1 | |
| SCHEMBL6507597 | 0.78 | SMN1; SMN2 (0.57) | AOC3SMN1; SMN2POLBTSHRL3MBTL1 | |
| SCHEMBL20714306 | 0.78 | AOC3 (0.50) | AOC3SMN1; SMN2POLBTSHRL3MBTL1 | |
| SCHEMBL9079266 | 0.78 | AOC3 (0.47) | AOC3SMN1; SMN2POLBTSHRL3MBTL1 | |
| SCHEMBL646758 | 0.78 | RAB9A (0.46) | SMN1; SMN2TSHRL3MBTL1MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508437-A | APPETITE SUPPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-04-16 | — | — | US | disclosed |
| US-5296608-A | Intermediates for analogs of tyrosine sulfate or tyrosine phosphate containing peptides | HOFFMAN-LA ROCHE INC. (US) | 1994-03-22 | — | — | US | disclosed |
| US-5182263-A | Appetite suppressants | HOFFMANN-LA ROCHE INC. (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0339549-A2 | Tyr-peptide analogs | F. HOFFMANN-LA ROCHE AG (CH) | 1989-11-02 | — | — | EP | disclosed |