SCHEMBL907962

SCHEMBL907962

O=C(O)Cc1cscn1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24554380 0.81
SCHEMBL860903 0.81
SCHEMBL19143642 0.80 PKM (0.45)
SCHEMBL4666843 0.80 PKM (0.49)
SCHEMBL907879 0.79 KDM4E (0.44)
SCHEMBL28076009 0.79 PKM (0.47)
SCHEMBL1758875 0.78 PKM (0.46)
SCHEMBL23118696 0.76 MAPK1 (0.47)
SCHEMBL5672910 0.76 MAPK1 (0.47)
SCHEMBL23118695 0.76 PKM (0.45)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 205 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109438385-A The preparation method of high-purity 2- amino -4- thiazolyl acetic acid 山东金城医药化工有限公司 2019-03-08 CN claimed
EP-2970118-B1 COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS MANFREDI JOHN (US) 2018-09-12 EP claimed
EP-2970118-A1 COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS Manfredi, John (US) 2016-01-20 EP claimed
US-9216966-B2 Compounds for Alzheimer's disease Manfredi, John (US) 2015-12-22 US claimed
EP-2931718-A1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT Merck Sharp & Dohme Corp. (US) 2015-10-21 EP claimed
WO-2014164222-A1 COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS MANFREDI JOHN (US) 2014-10-09 WO claimed
WO-2014099584-A1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT MERCK SHARP & DOHME CORP. (US) 2014-06-26 WO claimed
US-20130261118-A1 COMPOUNDS FOR ALZHEIMER'S DISEASE MANFREDI JOHN (US) 2013-10-03 US claimed
CN-102070553-B Synthesis method of thiazole-4-formaldehyde XIAN RUILIAN MODERN ELECTRONIC CHEMICALS CO LTD 2013-08-07 CN claimed
CN-102372680-A Method for preparing 4-thiazolecarboxylic acid UNIV CHANGZHOU 2012-03-14 CN claimed
EP-2207774-A1 TRIAZOLE DERIVATIVES AS SCD INHIBITORS GlaxoSmithKline LLC (US) 2010-07-21 EP claimed
CN-101633666-A Cefotiam hydrochloride compound in new path HAINAN SHUITIAN MEDICINE RES I 2010-01-27 CN claimed
WO-2009060054-A1 TRIAZOLE DERIVATIVES AS SCD INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2009-05-14 WO claimed
CN-101043918-A Cationic azacyanine dyes and colorants containing said dyes PROCTER & GAMBLE (US) 2007-09-26 CN claimed
CN-1186332-C Novel thyroid receptor ligands and method II KAROBIO AB (SE) 2005-01-26 CN claimed
US-6610845-B1 Reacting a thiazolyl acetic acid with a 1,2,5,6-tetrahdro-2-methyl-5,6 dioxo-1,2,4-triazin-3-thiol; Vilsmeier reagent ORCHID CHEMICALS & PHARMACEUTICALS LIMITED, INDIA (IN) 2003-08-26 US claimed
WO-2003059908-A1 NOVEL THIOESTER DERIVATIVES AND PROCESS FOR PREPARATION OF CEPHALOSPORIN ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) 2003-07-24 WO claimed
EP-1283831-A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 BIOVITRUM AB (SE) 2003-02-19 EP claimed
WO-2001090090-A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 BIOVITRUM AB (SE) 2001-11-29 WO claimed
CN-1308619-A (2-acylaminothiazol-4-yl) acetic acid derivatives AMERICAN HOME PROD (US) 2001-08-15 CN claimed