Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9078237 | 0.90 | NPC1 (0.56) | NPC1MAPTRAB9APRMT5MEN1 | |
| SCHEMBL979553 | 0.71 | HTR2A (0.40) | PRMT5KMT2ANOS2TLR8MCL1 | |
| SCHEMBL9203904 | 0.69 | DRD2 (0.56) | PRMT5HTR1A | |
| SCHEMBL18628737 | 0.69 | NPC1 (0.50) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL10633577 | 0.69 | NPC1 (0.50) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL5057519 | 0.69 | NPC1 (0.50) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL7424856 | 0.69 | NPC1 (0.50) | NPC1MAPTRAB9APRMT5MEN1 | |
| Hydrochloric Acid SCHEMBL7164365 | 0.66 | PARP1 (0.69) | — | |
| SCHEMBL4947911 | 0.66 | NPC1 (0.60) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL8548519 | 0.66 | MAPT (0.47) | NPC1MAPTRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5512590-A | PREVENTS DISORDER OF GABAERGIC TRANSMISSION | SYNTHELABO (FR) | 1996-04-30 | — | — | US | disclosed |
| EP-0682025-A1 | 5,6-dihydro-4H-imidazo 2',1':2,3 imidazo 4,5,1-ij quinoline and 4,5-dihydroimidazo 1,2-a pyrrolo 1,2,3-cd benzimidazol derivatives | SYNTHELABO (FR) | 1995-11-15 | — | — | EP | disclosed |