Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | HPGD | P15428 | 7/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.67 |
| ▸ | ALB | P02768 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.67 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.66 |
| ▸ | TUBB | P07437 | 1/20 | 0.66 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.66 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.66 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.66 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.66 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.66 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.66 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.66 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.66 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.66 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9080358 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| SCHEMBL9080476 | 0.97 | KDM4E (0.69) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| SCHEMBL9080479 | 0.97 | KDM4E (0.69) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Desmethyl-Ofloxacin SCHEMBL6246239 | 0.85 | KDM4E (0.81) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| N-Desmethyl Levofloxacin SCHEMBL5021672 | 0.85 | KDM4E (0.81) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Desmethyl-Ofloxacin SCHEMBL30542144 | 0.85 | KDM4E (0.81) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| N-Desmethyl Levofloxacin SCHEMBL30306092 | 0.85 | KDM4E (0.81) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| N-Desmethyl Levofloxacin SCHEMBL20577525 | 0.84 | KDM4E (0.79) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| Desmethyl-Ofloxacin SCHEMBL6247374 | 0.84 | KDM4E (0.79) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| SCHEMBL9079794 | 0.84 | LMNA (0.47) | KDM4EALDH1A1HPGDHSD17B10ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508428-A | Spiro compound | DAIICHI PHAMACEUTICAL CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| US-5286723-A | Spiro compound | DAIICHI SEIYAKU CO., LTD. | 1994-02-15 | — | — | US | disclosed |
| EP-0357047-B1 | Spiro compounds | DAIICHI SEIYAKU CO (JP) | 1993-11-03 | — | — | EP | disclosed |
| EP-0529688-A2 | Azaspiro n,m alkanes and diazaspiro n,m -alkanes | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| EP-0357047-A1 | Spiro compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-03-07 | — | — | EP | disclosed |