Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 9/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | BTK | Q06187 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810683 | 1.00 | DHODH (0.62) | DHODHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL5914890 | 0.93 | DHODH (0.70) | DHODHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL5914891 | 0.93 | DHODH (0.70) | DHODHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL8810121 | 0.89 | DHODH (0.74) | DHODHMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL9080958 | 0.89 | DHODH (0.74) | DHODHMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL8812418 | 0.87 | DHODH (0.63) | DHODHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL9081360 | 0.87 | DHODH (0.63) | DHODHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL8811901 | 0.86 | DHODH (0.62) | DHODHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL8811754 | 0.86 | DHODH (0.63) | DHODHMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL8809976 | 0.86 | DHODH (0.63) | DHODHMEN1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532259-A | ANTITUMOR | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-02 | — | — | US | disclosed |
| US-5494911-A | TREATING LEUKEMIA, SARCOMA, CARCINOMA, LYMPHOMA, SKIN CANCER | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-02-27 | — | — | US | disclosed |