Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 3/20 | 0.53 |
| ▸ | LTA4H | P09960 | 6/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | BAX | Q07812 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.42 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.42 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.42 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11151727 | 0.89 | FFAR1 (0.50) | FFAR1LTA4HSRD5A2TSHRFFAR4 | |
| SCHEMBL129338 | 0.81 | TDP1 (0.52) | TSHRMAOA | |
| SCHEMBL19322270 | 0.81 | LTA4H (0.67) | FFAR1LTA4HSRD5A2TSHRFFAR4 | |
| SCHEMBL28724005 | 0.79 | FFAR1 (0.64) | FFAR1LTA4HSRD5A2TSHRFFAR4 | |
| SCHEMBL7456192 | 0.78 | TDP1 (0.62) | FFAR1LTA4HSRD5A2TSHRFFAR4 | |
| SCHEMBL19322272 | 0.77 | FFAR1 (0.62) | FFAR1LTA4HSRD5A2TSHRFFAR4 | |
| SCHEMBL2201304 | 0.77 | FFAR1 (0.62) | FFAR1LTA4HSRD5A2TSHRFFAR4 | |
| SCHEMBL23573012 | 0.77 | FFAR1 (0.61) | FFAR1LTA4HSRD5A2TSHRFFAR4 | |
| SCHEMBL1295195 | 0.76 | TAAR1 (0.55) | LTA4H | |
| SCHEMBL12514597 | 0.75 | ALDH1A1 (0.61) | FFAR1LTA4HSRD5A2TSHRFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |
| EP-0024943-B1 | 5,6,7-TRINOR-4,8-INTER-M-PHENYLENE PGI2 DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TORAY INDUSTRIES, INC. (JP) | 1983-08-17 | — | — | EP | disclosed |
| US-4301164-A | FOR USE AS ANTIULCER AGENTS, HYPOTENSIVE AGENTS, ANTITHROMBOSIC AGENTS | TORAY INDUSTRIES, INC. (JP) | 1981-11-17 | — | — | US | disclosed |
| EP-0024943-A1 | 5,6,7-Trinor-4,8-inter-m-phenylene PGI2 derivatives and pharmaceutical compositions containing them | TORAY INDUSTRIES, INC. (JP) | 1981-03-11 | — | — | EP | disclosed |