Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | HTR2A | P28223 | 4/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9081613 | 0.90 | MEN1 (0.65) | KDM4EMEN1KMT2AALDH1A1HTR2A | |
| SCHEMBL9080552 | 0.88 | ALDH1A1 (0.76) | KDM4EMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL9081633 | 0.86 | ALDH1A1 (0.66) | KDM4EMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL13973034 | 0.80 | ALDH1A1 (0.52) | KDM4EMEN1KMT2AALDH1A1HTR2A | |
| SCHEMBL9079986 | 0.79 | MAPK1 (0.70) | KDM4EMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL5947311 | 0.78 | BCHE (0.64) | KDM4EMEN1KMT2AALDH1A1HTR2A | |
| SCHEMBL30877044 | 0.76 | MAPK1 (0.77) | KDM4EMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL27312115 | 0.76 | MAPK1 (0.77) | KDM4EMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL9081356 | 0.75 | KDM4E (1.00) | KDM4EMEN1KMT2AALDH1A1HTT | |
| SCHEMBL13958862 | 0.74 | HTR2A (0.45) | KDM4EALDH1A1HTR2ASLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |