Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6482526 | 0.86 | KMT2A (0.54) | KMT2ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL27846222 | 0.86 | KMT2A (0.60) | KMT2ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL537442 | 0.84 | MAPT (0.61) | KMT2ANPC1NPSR1ALDH1A1CES2 | |
| SCHEMBL7609860 | 0.83 | KMT2A (0.50) | KMT2ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL7673359 | 0.81 | AKR1C3 (0.61) | KMT2ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL1331831 | 0.81 | AKR1C3 (0.57) | KMT2ANPSR1ALDH1A1LMNAMAPT | |
| SCHEMBL64069 | 0.81 | AKR1C3 (0.57) | KMT2ANPSR1ALDH1A1LMNAMAPT | |
| SCHEMBL9490579 | 0.80 | MAPT (0.53) | KMT2ANPC1SMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL7044239 | 0.80 | LIG1 (0.61) | KMT2AALDH1A1CES2HTTLMNA | |
| SCHEMBL9851196 | 0.80 | KMT2A (0.70) | KMT2ANPC1SMN1; SMN2NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745065-A1 | 9-(SUBSTITUTED AMINO)-ALPHA-6-DEOXY-5-OXY TETRACYCLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIBIOTICS | PFIZER INC. (US) | 1996-12-04 | — | — | EP | disclosed |
| EP-0668889-A1 | STABILIZER MIXTURES CONTAINING GARNET-CLASS COMPOUNDS FOR POLYMERS. | HENKEL KGAA (DE) | 1995-08-30 | — | — | EP | disclosed |
| WO-1995022529-A1 | 9-(SUBSTITUTED AMINO)-ALPHA-6-DEOXY-5-OXY TETRACYCLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIBIOTICS | PFIZER INC. (US) | 1995-08-24 | — | — | WO | disclosed |
| WO-1994011431-A1 | STABILIZER MIXTURES CONTAINING GARNET-CLASS COMPOUNDS FOR POLYMERS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1994-05-26 | — | — | WO | disclosed |